Noradrenaline activation of hippocampal dopamine D(1) receptors promotes antidepressant effects

Dopamine D(1) receptors (D(1)Rs) in the hippocampal dentate gyrus (DG) are essential for antidepressant effects. However, the midbrain dopaminergic neurons, the major source of dopamine in the brain, only sparsely project to DG, suggesting possible activation of DG D(1)Rs by endogenous substances ot...

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Detalles Bibliográficos
Autores principales: Kobayashi, Katsunori, Shikano, Kisako, Kuroiwa, Mahomi, Horikawa, Mio, Ito, Wakana, Nishi, Akinori, Segi-Nishida, Eri, Suzuki, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388128/
https://www.ncbi.nlm.nih.gov/pubmed/35939697
http://dx.doi.org/10.1073/pnas.2117903119

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