Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na(v)1.7

Voltage-gated sodium (Na(v)) channel Na(v)1.7 has been targeted for the development of nonaddictive pain killers. Structures of Na(v)1.7 in distinct functional states will offer an advanced mechanistic understanding and aid drug discovery. Here we report the cryoelectron microscopy analysis of a hum...

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Detalles Bibliográficos
Autores principales: Huang, Gaoxingyu, Wu, Qiurong, Li, Zhangqiang, Jin, Xueqin, Huang, Xiaoshuang, Wu, Tong, Pan, Xiaojing, Yan, Nieng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388133/
https://www.ncbi.nlm.nih.gov/pubmed/35878056
http://dx.doi.org/10.1073/pnas.2209164119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388133/
https://www.ncbi.nlm.nih.gov/pubmed/35878056
http://dx.doi.org/10.1073/pnas.2209164119

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