Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons

Epilepsy is a common neurological disorder, which has been linked to mutations or deletions of RNA binding protein, fox-1 homolog (Caenorhabditis elegans) 3 (RBFOX3)/NeuN, a neuronal splicing regulator. However, the mechanism of seizure mediation by RBFOX3 remains unknown. Here, we show that mice wi...

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Detalles Bibliográficos
Autores principales: Huang, De-Fong, Lee, Chih-Yu, Chou, Ming-Yi, Yang, Tzu-Yin, Cao, Xuhui, Hsiao, Yu-Hsuan, Wu, Rui-Ni, Lien, Cheng-Chang, Huang, Yi-Shuian, Huang, Hsiang-Po, Gau, Susan Shur-Fen, Huang, Hsien-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388145/
https://www.ncbi.nlm.nih.gov/pubmed/35951651
http://dx.doi.org/10.1073/pnas.2203632119

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