Dexmedetomidine suppresses serum syndecan-1 elevation and improves survival in a rat hemorrhagic shock model

Hemorrhagic shock causes vascular endothelial glycocalyx (EGCX) damage and systemic inflammation. Dexmedetomidine (DEX) has anti-inflammatory and EGCX-protective effects, but its effect on hemorrhagic shock has not been investigated. Therefore, we investigated whether DEX reduces inflammation and pr...

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Detalles Bibliográficos
Autores principales: Kobayashi, Atsushi, Mimuro, Soichiro, Katoh, Takasumi, Kobayashi, Kensuke, Sato, Tsunehisa, Kien, Truong Sang, Nakajima, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2022
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388338/
https://www.ncbi.nlm.nih.gov/pubmed/35110424
http://dx.doi.org/10.1538/expanim.21-0186

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