The role of microglia in neuropsychiatric disorders and suicide

This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychi...

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Autores principales: Brisch, Ralf, Wojtylak, Szymon, Saniotis, Arthur, Steiner, Johann, Gos, Tomasz, Kumaratilake, Jaliya, Henneberg, Maciej, Wolf, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388452/
https://www.ncbi.nlm.nih.gov/pubmed/34595576
http://dx.doi.org/10.1007/s00406-021-01334-z
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author Brisch, Ralf
Wojtylak, Szymon
Saniotis, Arthur
Steiner, Johann
Gos, Tomasz
Kumaratilake, Jaliya
Henneberg, Maciej
Wolf, Rainer
author_facet Brisch, Ralf
Wojtylak, Szymon
Saniotis, Arthur
Steiner, Johann
Gos, Tomasz
Kumaratilake, Jaliya
Henneberg, Maciej
Wolf, Rainer
author_sort Brisch, Ralf
collection PubMed
description This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders.
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spelling pubmed-93884522022-08-20 The role of microglia in neuropsychiatric disorders and suicide Brisch, Ralf Wojtylak, Szymon Saniotis, Arthur Steiner, Johann Gos, Tomasz Kumaratilake, Jaliya Henneberg, Maciej Wolf, Rainer Eur Arch Psychiatry Clin Neurosci Invited Review This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders. Springer Berlin Heidelberg 2021-09-30 2022 /pmc/articles/PMC9388452/ /pubmed/34595576 http://dx.doi.org/10.1007/s00406-021-01334-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Invited Review
Brisch, Ralf
Wojtylak, Szymon
Saniotis, Arthur
Steiner, Johann
Gos, Tomasz
Kumaratilake, Jaliya
Henneberg, Maciej
Wolf, Rainer
The role of microglia in neuropsychiatric disorders and suicide
title The role of microglia in neuropsychiatric disorders and suicide
title_full The role of microglia in neuropsychiatric disorders and suicide
title_fullStr The role of microglia in neuropsychiatric disorders and suicide
title_full_unstemmed The role of microglia in neuropsychiatric disorders and suicide
title_short The role of microglia in neuropsychiatric disorders and suicide
title_sort role of microglia in neuropsychiatric disorders and suicide
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388452/
https://www.ncbi.nlm.nih.gov/pubmed/34595576
http://dx.doi.org/10.1007/s00406-021-01334-z
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