HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development

Allergic rhinitis and asthma are the most common causes of chronic inflammation of the upper and lower airways in childhood. However, a nasal biomarker that can link to pulmonary inflammation is yet to be found. The present paper aims to investigate the possible role in inflammation of two inducible...

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Autores principales: Fagotti, Anna, Lucentini, Livia, Simoncelli, Francesca, La Porta, Gianandrea, Brustenga, Leonardo, Bizzarri, Ilaria, Trio, Silvia, Isidori, Chiara, Di Rosa, Ines, Di Cara, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388484/
https://www.ncbi.nlm.nih.gov/pubmed/35982171
http://dx.doi.org/10.1038/s41598-022-18443-x
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author Fagotti, Anna
Lucentini, Livia
Simoncelli, Francesca
La Porta, Gianandrea
Brustenga, Leonardo
Bizzarri, Ilaria
Trio, Silvia
Isidori, Chiara
Di Rosa, Ines
Di Cara, Giuseppe
author_facet Fagotti, Anna
Lucentini, Livia
Simoncelli, Francesca
La Porta, Gianandrea
Brustenga, Leonardo
Bizzarri, Ilaria
Trio, Silvia
Isidori, Chiara
Di Rosa, Ines
Di Cara, Giuseppe
author_sort Fagotti, Anna
collection PubMed
description Allergic rhinitis and asthma are the most common causes of chronic inflammation of the upper and lower airways in childhood. However, a nasal biomarker that can link to pulmonary inflammation is yet to be found. The present paper aims to investigate the possible role in inflammation of two inducible 70-kDa Heat Shock Proteins (HSP70) members, HSPA1A/B and HSPA6, in nasal mucosa cells of allergic children through their mRNA expression analysis, and their correlation to both spirometric and FeNO values. The relationship between FeNO in lower airways and ∆Cts of HSPA1A/B in nasal mucosa seems to be influenced by clinical symptoms regardless of age, sex, and sensitization patterns. Therefore, HSP70 expression, as well as FeNO levels, could have a predictive capability to identify lower airways inflammation and thus to recognize rhinitic children having a potential risk of asthma development.
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spelling pubmed-93884842022-08-20 HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development Fagotti, Anna Lucentini, Livia Simoncelli, Francesca La Porta, Gianandrea Brustenga, Leonardo Bizzarri, Ilaria Trio, Silvia Isidori, Chiara Di Rosa, Ines Di Cara, Giuseppe Sci Rep Article Allergic rhinitis and asthma are the most common causes of chronic inflammation of the upper and lower airways in childhood. However, a nasal biomarker that can link to pulmonary inflammation is yet to be found. The present paper aims to investigate the possible role in inflammation of two inducible 70-kDa Heat Shock Proteins (HSP70) members, HSPA1A/B and HSPA6, in nasal mucosa cells of allergic children through their mRNA expression analysis, and their correlation to both spirometric and FeNO values. The relationship between FeNO in lower airways and ∆Cts of HSPA1A/B in nasal mucosa seems to be influenced by clinical symptoms regardless of age, sex, and sensitization patterns. Therefore, HSP70 expression, as well as FeNO levels, could have a predictive capability to identify lower airways inflammation and thus to recognize rhinitic children having a potential risk of asthma development. Nature Publishing Group UK 2022-08-18 /pmc/articles/PMC9388484/ /pubmed/35982171 http://dx.doi.org/10.1038/s41598-022-18443-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Fagotti, Anna
Lucentini, Livia
Simoncelli, Francesca
La Porta, Gianandrea
Brustenga, Leonardo
Bizzarri, Ilaria
Trio, Silvia
Isidori, Chiara
Di Rosa, Ines
Di Cara, Giuseppe
HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
title HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
title_full HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
title_fullStr HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
title_full_unstemmed HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
title_short HSP70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
title_sort hsp70 upregulation in nasal mucosa of symptomatic children with allergic rhinitis and potential risk of asthma development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388484/
https://www.ncbi.nlm.nih.gov/pubmed/35982171
http://dx.doi.org/10.1038/s41598-022-18443-x
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