Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life

Antibody-based therapeutics (ABTs) are used to treat a range of diseases. Most ABTs are either full-length IgG1 antibodies or fusions between for instance antigen (Ag)-binding receptor domains and the IgG1 Fc fragment. Interestingly, their plasma half-life varies considerably, which may relate to ho...

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Detalles Bibliográficos
Autores principales: Gjølberg, Torleif Tollefsrud, Frick, Rahel, Mester, Simone, Foss, Stian, Grevys, Algirdas, Høydahl, Lene Støkken, Jørstad, Øystein Kalsnes, Schlothauer, Tilman, Sandlie, Inger, Moe, Morten C., Andersen, Jan Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388496/
https://www.ncbi.nlm.nih.gov/pubmed/35982144
http://dx.doi.org/10.1038/s42003-022-03787-x

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