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The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels
We aimed to determine whether vitamin D levels before prostate biopsy have diagnostic value for clinically significant prostate cancer. The study cohort included patients who underwent prostate biopsy. A total of 224 patients were enrolled in our study and serum vitamin D levels were measured from F...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388499/ https://www.ncbi.nlm.nih.gov/pubmed/35982094 http://dx.doi.org/10.1038/s41598-022-17563-8 |
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author | Kim, Min Hyuk Yoo, Sangjun Choo, Min Soo Cho, Min Chul Son, Hwancheol Jeong, Hyeon |
author_facet | Kim, Min Hyuk Yoo, Sangjun Choo, Min Soo Cho, Min Chul Son, Hwancheol Jeong, Hyeon |
author_sort | Kim, Min Hyuk |
collection | PubMed |
description | We aimed to determine whether vitamin D levels before prostate biopsy have diagnostic value for clinically significant prostate cancer. The study cohort included patients who underwent prostate biopsy. A total of 224 patients were enrolled in our study and serum vitamin D levels were measured from February 2016 to December 2019 in routine laboratory tests. To determine the relationship between vitamin D levels and aggressiveness of prostate cancer, we used logistic multivariate analysis. Based on the histopathological results of patients who underwent radical prostatectomy, the serum vitamin D level was significantly lower with the large tumor volume group. In the univariate analysis, the prostate cancer diagnosis rate was associated with low vitamin D levels. Low vitamin D level is negatively correlated with clinically significant prostate cancer (biopsy Gleason score of 7 or higher) in the univariate (Odds ratio [OR], 0.955; P < 0.001) and multivariate (OR, 0.944; P = 0.027) analyses. In conclusion, we found that the incidence of clinically significant prostate cancer might related to low vitamin D level in the Asian population. In the future, a larger population and prospective study are needed. |
format | Online Article Text |
id | pubmed-9388499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93884992022-08-20 The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels Kim, Min Hyuk Yoo, Sangjun Choo, Min Soo Cho, Min Chul Son, Hwancheol Jeong, Hyeon Sci Rep Article We aimed to determine whether vitamin D levels before prostate biopsy have diagnostic value for clinically significant prostate cancer. The study cohort included patients who underwent prostate biopsy. A total of 224 patients were enrolled in our study and serum vitamin D levels were measured from February 2016 to December 2019 in routine laboratory tests. To determine the relationship between vitamin D levels and aggressiveness of prostate cancer, we used logistic multivariate analysis. Based on the histopathological results of patients who underwent radical prostatectomy, the serum vitamin D level was significantly lower with the large tumor volume group. In the univariate analysis, the prostate cancer diagnosis rate was associated with low vitamin D levels. Low vitamin D level is negatively correlated with clinically significant prostate cancer (biopsy Gleason score of 7 or higher) in the univariate (Odds ratio [OR], 0.955; P < 0.001) and multivariate (OR, 0.944; P = 0.027) analyses. In conclusion, we found that the incidence of clinically significant prostate cancer might related to low vitamin D level in the Asian population. In the future, a larger population and prospective study are needed. Nature Publishing Group UK 2022-08-18 /pmc/articles/PMC9388499/ /pubmed/35982094 http://dx.doi.org/10.1038/s41598-022-17563-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Min Hyuk Yoo, Sangjun Choo, Min Soo Cho, Min Chul Son, Hwancheol Jeong, Hyeon The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
title | The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
title_full | The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
title_fullStr | The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
title_full_unstemmed | The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
title_short | The role of the serum 25-OH vitamin D level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
title_sort | role of the serum 25-oh vitamin d level on detecting prostate cancer in men with elevated prostate-specific antigen levels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388499/ https://www.ncbi.nlm.nih.gov/pubmed/35982094 http://dx.doi.org/10.1038/s41598-022-17563-8 |
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