Tanshinone IIA reduces AQP4 expression and astrocyte swelling after OGD/R by inhibiting the HMGB1/RAGE/NF-κB/IL-6 pro-inflammatory axis

This study aimed to investigate the role of tanshinone IIA (TSO IIA) in astrocytic swelling caused by ischemia–reperfusion-like injury in an in vitro model and the molecular mechanisms underlying this effect. Primary brain astrocytes were cultured under conditions of glucose and oxygen deprivation a...

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Detalles Bibliográficos
Autores principales: Tang, Zhaohua, Yang, Gang, Liao, Zhengbu, Chen, Feilan, Chen, Song, Wang, Wentao, Huo, Gang, Sun, Xiaochuan, Wang, Xiaoshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388613/
https://www.ncbi.nlm.nih.gov/pubmed/35982135
http://dx.doi.org/10.1038/s41598-022-17491-7

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