Cargando…

Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2

Distant metastasis is the primary cause of breast cancer-associated death. The existing information, such as the precise molecular mechanisms and effective therapeutic strategies targeting metastasis, is insufficient to combat breast cancer. This study demonstrates that the protein tyrosine phosphat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Tao, Ba, Xinlei, Zhang, Xiaonan, Zhang, Na, Wang, Guowen, Bai, Bin, Li, Tong, Zhao, Jiahui, Zhao, Yanjiao, Yu, Yang, Wang, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388692/ https://www.ncbi.nlm.nih.gov/pubmed/35982039 http://dx.doi.org/10.1038/s41419-022-05167-z

Ejemplares similares

PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression
por: Wang, Tao, et al.
Publicado: (2023)

The Tyrosine Phosphatase Activity of PTPN22 Is Involved in T Cell Development via the Regulation of TCR Expression
por: Bai, Bin, et al.
Publicado: (2023)

Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer
por: Wang, Tao, et al.
Publicado: (2022)

Nuclear importin α and its physiological importance
por: Miyamoto, Yoichi, et al.
Publicado: (2012)

Stimulated nuclear import by β-like importins
por: Flores, Karen, et al.
Publicado: (2013)

MVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions
por: Duval, Damien, et al.
Publicado: (2015)

MVP: a microbe–phage interaction database
por: Gao, Na L, et al.
Publicado: (2018)

Nuclear import time and transport efficiency depend on importin β concentration
por: Yang, Weidong, et al.
Publicado: (2006)

Determination of the Functional Domain Organization of the Importin α Nuclear Import Factor
por: Herold, Andrea, et al.
Publicado: (1998)

Yeast importin-β is required for nuclear import of the Mig2 repressor
por: Fernández-Cid, Alejandra, et al.
Publicado: (2012)

Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import
por: Ben-Efraim, Iris, et al.
Publicado: (2001)

The adapter importin-α provides flexible control of nuclear import at the expense of efficiency
por: Riddick, Greg, et al.
Publicado: (2007)

A systems analysis of importin-α–β mediated nuclear protein import
por: Riddick, Gregory, et al.
Publicado: (2005)

Higher Nucleoporin-Importinβ Affinity at the Nuclear Basket Increases Nucleocytoplasmic Import
por: Azimi, Mohammad, et al.
Publicado: (2013)

UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner
por: Li, Zhengke, et al.
Publicado: (2013)

MVP predicts the pathogenicity of missense variants by deep learning
por: Qi, Hongjian, et al.
Publicado: (2021)

Importin α5 negatively regulates importin β1-mediated nuclear import of Newcastle disease virus matrix protein and viral replication and pathogenicity in chicken fibroblasts
por: Duan, Zhiqiang, et al.
Publicado: (2018)

Cellular stresses induce the nuclear accumulation of importin α and cause a conventional nuclear import block
por: Miyamoto, Yoichi, et al.
Publicado: (2004)

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome
por: Zaitseva, Lyubov, et al.
Publicado: (2009)

Importin 7 and Nup358 Promote Nuclear Import of the Protein Component of Human Telomerase
por: Frohnert, Cornelia, et al.
Publicado: (2014)

Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins
por: Eldridge, Matthew J. G., et al.
Publicado: (2020)

Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
por: García-García, María, et al.
Publicado: (2022)

SQL Server MVP deep dives
por: Nielsen, Paul
Publicado: (2010)

SQL Server MVP deep dives.
por: Delaney, Kalen, et al.
Publicado: (2012)

A New Malignant MVP Phenotype?
por: Thamman, Ritu
Publicado: (2021)

Importin-beta-like nuclear transport receptors
por: Ström, Anne-Christine, et al.
Publicado: (2001)

Importin-7 Mediates Nuclear Trafficking of DNA in Mammalian Cells
por: Dhanoya, Arjun, et al.
Publicado: (2013)

Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor: Role in Cell Proliferation
por: Reilly, John F., et al.
Publicado: (2001)

Importin β contains a COOH-terminal nucleoporin binding region important for nuclear transport
por: Bednenko, Janna, et al.
Publicado: (2003)

Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-β1
por: Cimica, Velasco, et al.
Publicado: (2011)

Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
por: Roman, Noelia, et al.
Publicado: (2013)

MVP and vaults: a role in the radiation response
por: Lara, Pedro C, et al.
Publicado: (2011)

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions
por: Jung, Hunmin, et al.
Publicado: (2020)

MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells
por: Pietras, Paulina, et al.
Publicado: (2021)

The nuclear import of Frizzled2-C by Importins-β11 and α2 promotes postsynaptic development
por: Mosca, Timothy J., et al.
Publicado: (2010)

Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme
por: Moutty, Marie Christine, et al.
Publicado: (2011)

A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
por: Pardal, Alonso Javier, et al.
Publicado: (2022)

The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain
por: Lieu, Kim G., et al.
Publicado: (2014)

Successful embolization of a congenital intra-hepatic arterioportal fistula in a neonate with the MVP Microvascular Plug system (MVP-3Q)
por: Gladkikh, Maria, et al.
Publicado: (2022)

The cryo-EM structure of the SNX–BAR Mvp1 tetramer
por: Sun, Dapeng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9224i930emjmtrpta6985gom7t