Fingolimod does not prevent syndecan-4 shedding from the endothelial glycocalyx in a cultured human umbilical vein endothelial cell model of vascular injury

BACKGROUND: Shedding of the endothelial glycocalyx (EG) is associated with poor outcomes in a range of conditions including sepsis. Fresh frozen plasma (FFP) restores the damaged EG to baseline thickness, however the mechanism for this effect is unknown, and some components of FFP have adverse effec...

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Detalles Bibliográficos
Autores principales: Milford, Elissa M., Meital, Lara, Kuballa, Anna, Reade, Michael C., Russell, Fraser D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388705/
https://www.ncbi.nlm.nih.gov/pubmed/35980492
http://dx.doi.org/10.1186/s40635-022-00462-7

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