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Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9

Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and LDL/HDL ratio have been associated with new-onset diabetes; however, their cut-off levels have not been determined. We clarified the association between dyslipidemia and the incidence of diabetes. People who u...

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Autores principales: Kobayashi, Genki, Okada, Hiroshi, Hamaguchi, Masahide, Kurogi, Kazushiro, Murata, Hiroaki, Ito, Masato, Fukui, Michiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388748/
https://www.ncbi.nlm.nih.gov/pubmed/35992095
http://dx.doi.org/10.3389/fendo.2022.957728
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author Kobayashi, Genki
Okada, Hiroshi
Hamaguchi, Masahide
Kurogi, Kazushiro
Murata, Hiroaki
Ito, Masato
Fukui, Michiaki
author_facet Kobayashi, Genki
Okada, Hiroshi
Hamaguchi, Masahide
Kurogi, Kazushiro
Murata, Hiroaki
Ito, Masato
Fukui, Michiaki
author_sort Kobayashi, Genki
collection PubMed
description Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and LDL/HDL ratio have been associated with new-onset diabetes; however, their cut-off levels have not been determined. We clarified the association between dyslipidemia and the incidence of diabetes. People who underwent a health checkup under a program conducted by Panasonic Corporation from 2008 to 2018 were included. In total, 87,570 participants were included, of whom 5,110 developed type 2 diabetes. Cox regression analyses and time-dependent receiver operating characteristic (ROC) curves were used to evaluate the association between LDL cholesterol, HDL cholesterol, or LDL/HDL ratio and incident diabetes and to identify the cut-off values for incident diabetes. Multivariate analysis showed that LDL cholesterol, HDL cholesterol, and LDL/HDL ratio were significantly associated with the risk of incident type 2 diabetes. Further, the area under the ROC curve and optimized cut-off values for LDL cholesterol, HDL cholesterol, and LDL/HDL ratio for incident type 2 diabetes at 10 years were 0.613 and 124 mg/dl, 0.640 and 54 mg/dl, and 0.662 and 2.4 mg/dl, respectively. The LDL/HDL ratio with a cut-off value of 2.4 was a better predictor of incident diabetes within 10 years than LDL and HDL cholesterol.
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spelling pubmed-93887482022-08-20 Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9 Kobayashi, Genki Okada, Hiroshi Hamaguchi, Masahide Kurogi, Kazushiro Murata, Hiroaki Ito, Masato Fukui, Michiaki Front Endocrinol (Lausanne) Endocrinology Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and LDL/HDL ratio have been associated with new-onset diabetes; however, their cut-off levels have not been determined. We clarified the association between dyslipidemia and the incidence of diabetes. People who underwent a health checkup under a program conducted by Panasonic Corporation from 2008 to 2018 were included. In total, 87,570 participants were included, of whom 5,110 developed type 2 diabetes. Cox regression analyses and time-dependent receiver operating characteristic (ROC) curves were used to evaluate the association between LDL cholesterol, HDL cholesterol, or LDL/HDL ratio and incident diabetes and to identify the cut-off values for incident diabetes. Multivariate analysis showed that LDL cholesterol, HDL cholesterol, and LDL/HDL ratio were significantly associated with the risk of incident type 2 diabetes. Further, the area under the ROC curve and optimized cut-off values for LDL cholesterol, HDL cholesterol, and LDL/HDL ratio for incident type 2 diabetes at 10 years were 0.613 and 124 mg/dl, 0.640 and 54 mg/dl, and 0.662 and 2.4 mg/dl, respectively. The LDL/HDL ratio with a cut-off value of 2.4 was a better predictor of incident diabetes within 10 years than LDL and HDL cholesterol. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9388748/ /pubmed/35992095 http://dx.doi.org/10.3389/fendo.2022.957728 Text en Copyright © 2022 Kobayashi, Okada, Hamaguchi, Kurogi, Murata, Ito and Fukui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Kobayashi, Genki
Okada, Hiroshi
Hamaguchi, Masahide
Kurogi, Kazushiro
Murata, Hiroaki
Ito, Masato
Fukui, Michiaki
Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9
title Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9
title_full Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9
title_fullStr Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9
title_full_unstemmed Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9
title_short Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9
title_sort dyslipidemia and 10-year diabetes incidence in japanese people: population-based panasonic cohort study 9
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388748/
https://www.ncbi.nlm.nih.gov/pubmed/35992095
http://dx.doi.org/10.3389/fendo.2022.957728
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