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Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction

Adeno-associated virus (AAV) gene therapy has been successfully applied in hemophilia patients excluding patients with inhibitors. During the coagulation pathway, activated factor V (FVa) functions downstream as a cofactor of activated factor X (FXa) to amplify thrombin generation. We hypothesize th...

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Detalles Bibliográficos
Autores principales:	Sun, Junjiang, Chen, Xiaojing, Chai, Zheng, Niu, Hongqian, Dobbins, Amanda L., Nichols, Timothy C., Li, Chengwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388760/ https://www.ncbi.nlm.nih.gov/pubmed/35991645 http://dx.doi.org/10.3389/fmed.2022.880763

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