Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population

BACKGROUND AND AIMS: Thiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with monoethnic populations. We aimed to investigate...

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Detalles Bibliográficos
Autores principales: Khoo, Xin-Hui, Wong, Shin Yee, Ibrahim, Nik Razima Wan, Ng, Ruey Terng, Chew, Kee Seang, Lee, Way Seah, Wong, Zhi Qin, Raja Ali, Raja Affend, Shahrani, Shahreedhan, Leow, Alex Hwong-Ruey, Hilmi, Ida Normiha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388767/
https://www.ncbi.nlm.nih.gov/pubmed/35991642
http://dx.doi.org/10.3389/fmed.2022.880937

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