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Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study

OBJECTIVE: For patients with drug–resistant focal epilepsy, intracranial monitoring remains the gold standard for surgical intervention. Focal cortical dysplasia (FCD) is the most common cause of pharmacoresistant focal epilepsy in pediatric patients who usually develop seizures in early childhood....

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Autores principales: Wang, Zhi Ji, Noh, Byoung Ho, Kim, Eun Seong, Yang, Donghwa, Yang, Shan, Kim, Nam Young, Hur, Yun Jung, Kim, Heung Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388828/
https://www.ncbi.nlm.nih.gov/pubmed/35989902
http://dx.doi.org/10.3389/fneur.2022.901633
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author Wang, Zhi Ji
Noh, Byoung Ho
Kim, Eun Seong
Yang, Donghwa
Yang, Shan
Kim, Nam Young
Hur, Yun Jung
Kim, Heung Dong
author_facet Wang, Zhi Ji
Noh, Byoung Ho
Kim, Eun Seong
Yang, Donghwa
Yang, Shan
Kim, Nam Young
Hur, Yun Jung
Kim, Heung Dong
author_sort Wang, Zhi Ji
collection PubMed
description OBJECTIVE: For patients with drug–resistant focal epilepsy, intracranial monitoring remains the gold standard for surgical intervention. Focal cortical dysplasia (FCD) is the most common cause of pharmacoresistant focal epilepsy in pediatric patients who usually develop seizures in early childhood. Timely removal of the epileptogenic zone (EZ) is necessary to achieve lasting seizure freedom and favorable developmental and cognitive outcomes to improve the quality of life. We applied brain network analysis to investigate potential biomarkers for the diagnosis of EZ that will aid in the resection for pediatric focal epilepsy patients with FCD type II. METHODS: Ten pediatric patients with focal epilepsy diagnosed as FCD type II and that had a follow–up after resection surgery (Engel class I [n = 9] and Engel class II [n = 1]) were retrospectively included. Time–frequency analysis of phase transfer entropy, graph theory analysis, and power spectrum compensation were combined to calculate brain network parameters based on interictal epileptiform discharges from ECoG. RESULTS: Clustering coefficient, local efficiency, node out–degree, and node out–strength with higher values are the most reliable biomarkers for the delineation of EZ, and the differences between EZ and margin zone (MZ), and EZ and normal zone (NZ) were significant (p < 0.05; Mann–Whitney U-test, two–tailed). In particular, the difference between MZ and NZ was significant for patients with frontal FCD (MZ > NZ; p < 0.05) but was not significant for patients with extra–frontal FCD. CONCLUSIONS: Brain network analysis, based on the combination of time–frequency analysis of phase transfer entropy, graph theory analysis, and power spectrum compensation, can aid in the diagnosis of EZ for pediatric focal epilepsy patients with FCD type II.
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spelling pubmed-93888282022-08-20 Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study Wang, Zhi Ji Noh, Byoung Ho Kim, Eun Seong Yang, Donghwa Yang, Shan Kim, Nam Young Hur, Yun Jung Kim, Heung Dong Front Neurol Neurology OBJECTIVE: For patients with drug–resistant focal epilepsy, intracranial monitoring remains the gold standard for surgical intervention. Focal cortical dysplasia (FCD) is the most common cause of pharmacoresistant focal epilepsy in pediatric patients who usually develop seizures in early childhood. Timely removal of the epileptogenic zone (EZ) is necessary to achieve lasting seizure freedom and favorable developmental and cognitive outcomes to improve the quality of life. We applied brain network analysis to investigate potential biomarkers for the diagnosis of EZ that will aid in the resection for pediatric focal epilepsy patients with FCD type II. METHODS: Ten pediatric patients with focal epilepsy diagnosed as FCD type II and that had a follow–up after resection surgery (Engel class I [n = 9] and Engel class II [n = 1]) were retrospectively included. Time–frequency analysis of phase transfer entropy, graph theory analysis, and power spectrum compensation were combined to calculate brain network parameters based on interictal epileptiform discharges from ECoG. RESULTS: Clustering coefficient, local efficiency, node out–degree, and node out–strength with higher values are the most reliable biomarkers for the delineation of EZ, and the differences between EZ and margin zone (MZ), and EZ and normal zone (NZ) were significant (p < 0.05; Mann–Whitney U-test, two–tailed). In particular, the difference between MZ and NZ was significant for patients with frontal FCD (MZ > NZ; p < 0.05) but was not significant for patients with extra–frontal FCD. CONCLUSIONS: Brain network analysis, based on the combination of time–frequency analysis of phase transfer entropy, graph theory analysis, and power spectrum compensation, can aid in the diagnosis of EZ for pediatric focal epilepsy patients with FCD type II. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9388828/ /pubmed/35989902 http://dx.doi.org/10.3389/fneur.2022.901633 Text en Copyright © 2022 Wang, Noh, Kim, Yang, Yang, Kim, Hur and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wang, Zhi Ji
Noh, Byoung Ho
Kim, Eun Seong
Yang, Donghwa
Yang, Shan
Kim, Nam Young
Hur, Yun Jung
Kim, Heung Dong
Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study
title Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study
title_full Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study
title_fullStr Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study
title_full_unstemmed Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study
title_short Brain network analysis of interictal epileptiform discharges from ECoG to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type II: A retrospective study
title_sort brain network analysis of interictal epileptiform discharges from ecog to identify epileptogenic zone in pediatric patients with epilepsy and focal cortical dysplasia type ii: a retrospective study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388828/
https://www.ncbi.nlm.nih.gov/pubmed/35989902
http://dx.doi.org/10.3389/fneur.2022.901633
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