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Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021
To evaluate the use of asymptomatic surveillance, we implemented a surveillance program for asymptomatic SARS-CoV-2 infection in a voluntary sample of individuals at the College of Veterinary Medicine at the University of Minnesota. Self-collected anterior nasal samples were tested using real time r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388852/ https://www.ncbi.nlm.nih.gov/pubmed/35991058 http://dx.doi.org/10.3389/fpubh.2022.879107 |
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author | Mladonicky, Janice Bedada, Addisalem Yoder, Colin VanderWaal, Kimberly Torrison, Jerry Wells, Scott J. |
author_facet | Mladonicky, Janice Bedada, Addisalem Yoder, Colin VanderWaal, Kimberly Torrison, Jerry Wells, Scott J. |
author_sort | Mladonicky, Janice |
collection | PubMed |
description | To evaluate the use of asymptomatic surveillance, we implemented a surveillance program for asymptomatic SARS-CoV-2 infection in a voluntary sample of individuals at the College of Veterinary Medicine at the University of Minnesota. Self-collected anterior nasal samples were tested using real time reverse transcription-polymerase chain reaction (RT-PCR), in a 5:1 pooled testing strategy, twice weekly for 18 weeks. Positive pools were deconvoluted into individual tests, revealing an observed prevalence of 0.07% (3/4,525). Pooled testing allowed for large scale testing with an estimated cost savings of 79.3% and modeling demonstrated this testing strategy prevented up to 2 workplace transmission events, averting up to 4 clinical cases. At the study endpoint, antibody testing revealed 80.7% of participants had detectable vaccine antibody levels while 9.6% of participants had detectable antibodies to natural infection. |
format | Online Article Text |
id | pubmed-9388852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93888522022-08-20 Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 Mladonicky, Janice Bedada, Addisalem Yoder, Colin VanderWaal, Kimberly Torrison, Jerry Wells, Scott J. Front Public Health Public Health To evaluate the use of asymptomatic surveillance, we implemented a surveillance program for asymptomatic SARS-CoV-2 infection in a voluntary sample of individuals at the College of Veterinary Medicine at the University of Minnesota. Self-collected anterior nasal samples were tested using real time reverse transcription-polymerase chain reaction (RT-PCR), in a 5:1 pooled testing strategy, twice weekly for 18 weeks. Positive pools were deconvoluted into individual tests, revealing an observed prevalence of 0.07% (3/4,525). Pooled testing allowed for large scale testing with an estimated cost savings of 79.3% and modeling demonstrated this testing strategy prevented up to 2 workplace transmission events, averting up to 4 clinical cases. At the study endpoint, antibody testing revealed 80.7% of participants had detectable vaccine antibody levels while 9.6% of participants had detectable antibodies to natural infection. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9388852/ /pubmed/35991058 http://dx.doi.org/10.3389/fpubh.2022.879107 Text en Copyright © 2022 Mladonicky, Bedada, Yoder, VanderWaal, Torrison and Wells. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Mladonicky, Janice Bedada, Addisalem Yoder, Colin VanderWaal, Kimberly Torrison, Jerry Wells, Scott J. Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 |
title | Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 |
title_full | Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 |
title_fullStr | Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 |
title_full_unstemmed | Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 |
title_short | Pooled surveillance testing for asymptomatic SARS-CoV-2 infections at a Veterinary Teaching Hospital College, University of Minnesota, December 2020–April 2021 |
title_sort | pooled surveillance testing for asymptomatic sars-cov-2 infections at a veterinary teaching hospital college, university of minnesota, december 2020–april 2021 |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388852/ https://www.ncbi.nlm.nih.gov/pubmed/35991058 http://dx.doi.org/10.3389/fpubh.2022.879107 |
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