CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses

CD3-engaging bispecific antibodies (BsAbs) enable the formation of an immune synapse between T cells and tumor cells, resulting in robust target cell killing not dependent on a preexisting tumor specific T cell receptor. While recent studies have shed light on tumor cell-specific factors that modula...

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Detalles Bibliográficos
Autores principales: Molony, Ryan D., Funk, Theresa, Trabucco, Gina, Corcoran, Erik, Ruddy, David, Varadarajan, Malini, Elliot, GiNell, Piquet, Michelle, Lam, Joni, Meyer, Matthew J., Wang, Hui Qin, Kurtulus, Sema, Lu, Haihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388929/
https://www.ncbi.nlm.nih.gov/pubmed/35990699
http://dx.doi.org/10.3389/fimmu.2022.909979

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