Proton induced DNA double strand breaks at the Bragg peak: Evidence of enhanced LET effect

PURPOSE: To investigate DNA double strand breaks (DSBs) induced by therapeutic proton beams in plateau and Bragg peak to demonstrate DSB induction due to the higher LET in the Bragg peak. MATERIALS AND METHODS: pUC19 plasmid DNA samples were irradiated to doses of 1000 and 3000 Gy on a Mevion S250i...

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Detalles Bibliográficos
Autores principales: Frame, Cara M., Chen, Yu, Gagnon, Jonathan, Yuan, Y., Ma, Tianjun, Dritschilo, Anatoly, Pang, Dalong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388940/
https://www.ncbi.nlm.nih.gov/pubmed/35992825
http://dx.doi.org/10.3389/fonc.2022.930393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388940/
https://www.ncbi.nlm.nih.gov/pubmed/35992825
http://dx.doi.org/10.3389/fonc.2022.930393

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