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Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention

Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO inciden...

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Autores principales: Chen, Siqi, Qin, Chen, Fang, Qiuna, Duo, Lan, Wang, Mengting, Deng, Zhennv, Chen, Hao, Lin, Quankui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388942/
https://www.ncbi.nlm.nih.gov/pubmed/35992334
http://dx.doi.org/10.3389/fbioe.2022.930540
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author Chen, Siqi
Qin, Chen
Fang, Qiuna
Duo, Lan
Wang, Mengting
Deng, Zhennv
Chen, Hao
Lin, Quankui
author_facet Chen, Siqi
Qin, Chen
Fang, Qiuna
Duo, Lan
Wang, Mengting
Deng, Zhennv
Chen, Hao
Lin, Quankui
author_sort Chen, Siqi
collection PubMed
description Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO incidence, its preparations are time consuming and require tedious preparation steps. Herein, the thermoreversible agarose is adopted to prepare drug-eluting IOL. Such functional coating can be obtained easily by simple immersion in the antiproliferative drug containing hot agarose and taken out for cooling, which not only does not affect the optical property but also can effectively decrease the PCO incidence after intraocular implantation. As a result, the proposed agarose coating provides a rapid and economical alternative of drug-eluting IOL fabrication for PCO prevention.
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spelling pubmed-93889422022-08-20 Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention Chen, Siqi Qin, Chen Fang, Qiuna Duo, Lan Wang, Mengting Deng, Zhennv Chen, Hao Lin, Quankui Front Bioeng Biotechnol Bioengineering and Biotechnology Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs have been proved to be an effective way to prevent PCO incidence, its preparations are time consuming and require tedious preparation steps. Herein, the thermoreversible agarose is adopted to prepare drug-eluting IOL. Such functional coating can be obtained easily by simple immersion in the antiproliferative drug containing hot agarose and taken out for cooling, which not only does not affect the optical property but also can effectively decrease the PCO incidence after intraocular implantation. As a result, the proposed agarose coating provides a rapid and economical alternative of drug-eluting IOL fabrication for PCO prevention. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9388942/ /pubmed/35992334 http://dx.doi.org/10.3389/fbioe.2022.930540 Text en Copyright © 2022 Chen, Qin, Fang, Duo, Wang, Deng, Chen and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Chen, Siqi
Qin, Chen
Fang, Qiuna
Duo, Lan
Wang, Mengting
Deng, Zhennv
Chen, Hao
Lin, Quankui
Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
title Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
title_full Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
title_fullStr Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
title_full_unstemmed Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
title_short Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
title_sort rapid and economical drug-eluting iol preparation via thermoresponsive agarose coating for effective posterior capsular opacification prevention
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388942/
https://www.ncbi.nlm.nih.gov/pubmed/35992334
http://dx.doi.org/10.3389/fbioe.2022.930540
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