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Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients

BACKGROUND: The empirical basis for a quantitative assessment of the disease burden imposed by long-COVID is currently scant. We aimed to inform the disease burden caused by long-COVID in Japan. METHODS: We conducted a cross sectional self-report questionnaire survey. The questionnaire was mailed to...

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Autores principales: Tsuzuki, Shinya, Miyazato, Yusuke, Terada, Mari, Morioka, Shinichiro, Ohmagari, Norio, Beutels, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388960/
https://www.ncbi.nlm.nih.gov/pubmed/35986269
http://dx.doi.org/10.1186/s12955-022-02033-6
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author Tsuzuki, Shinya
Miyazato, Yusuke
Terada, Mari
Morioka, Shinichiro
Ohmagari, Norio
Beutels, Philippe
author_facet Tsuzuki, Shinya
Miyazato, Yusuke
Terada, Mari
Morioka, Shinichiro
Ohmagari, Norio
Beutels, Philippe
author_sort Tsuzuki, Shinya
collection PubMed
description BACKGROUND: The empirical basis for a quantitative assessment of the disease burden imposed by long-COVID is currently scant. We aimed to inform the disease burden caused by long-COVID in Japan. METHODS: We conducted a cross sectional self-report questionnaire survey. The questionnaire was mailed to 526 eligible patients, who were recovered from acute COVID-19 in April 2021. Answers were classified into two groups; participants who have no symptom and those who have any ongoing prolonged symptoms that lasted longer than four weeks at the time of the survey. We estimated the average treatment effect (ATE) of ongoing prolonged symptoms on EQ-VAS and EQ-5D-3L questionnaire using inverse probability weighting. In addition to symptom prolongation, we investigated whether other factors (including demography, lifestyle, and acute severity) were associated with low EQ-VAS and EQ-5D-3L values, by multivariable linear regression. RESULTS: 349 participants reported no symptoms and 108 reported any symptoms at the time of the survey. The participants who reported any symptoms showed a lower average value on the EQ-VAS (69.9 vs 82.8, respectively) and on the EQ-5D-3L (0.85 vs 0.96, respectively) than those reporting no symptoms considering the ATE of ongoing prolonged symptoms. The ATE of ongoing prolonged symptoms on EQ-VAS was − 12.9 [95% CI − 15.9 to − 9.8], and on the EQ-5D-3L it was − 0.11 [95% CI − 0.13 to − 0.09], implying prolonged symptoms have a negative impact on patients’ EQ-VAS and EQ-5D-3L score. In multivariable linear regression, only having prolonged symptoms was associated with lower scores (− 11.7 [95% CI − 15.0 to − 8.5] for EQ-VAS and − 0.10 [95% CI − 0.13 to − 0.08] for EQ-5D-3L). CONCLUSIONS: Due to their long duration, long-COVID symptoms represent a substantial disease burden expressed in impact on health-related quality of life.
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spelling pubmed-93889602022-08-19 Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients Tsuzuki, Shinya Miyazato, Yusuke Terada, Mari Morioka, Shinichiro Ohmagari, Norio Beutels, Philippe Health Qual Life Outcomes Research BACKGROUND: The empirical basis for a quantitative assessment of the disease burden imposed by long-COVID is currently scant. We aimed to inform the disease burden caused by long-COVID in Japan. METHODS: We conducted a cross sectional self-report questionnaire survey. The questionnaire was mailed to 526 eligible patients, who were recovered from acute COVID-19 in April 2021. Answers were classified into two groups; participants who have no symptom and those who have any ongoing prolonged symptoms that lasted longer than four weeks at the time of the survey. We estimated the average treatment effect (ATE) of ongoing prolonged symptoms on EQ-VAS and EQ-5D-3L questionnaire using inverse probability weighting. In addition to symptom prolongation, we investigated whether other factors (including demography, lifestyle, and acute severity) were associated with low EQ-VAS and EQ-5D-3L values, by multivariable linear regression. RESULTS: 349 participants reported no symptoms and 108 reported any symptoms at the time of the survey. The participants who reported any symptoms showed a lower average value on the EQ-VAS (69.9 vs 82.8, respectively) and on the EQ-5D-3L (0.85 vs 0.96, respectively) than those reporting no symptoms considering the ATE of ongoing prolonged symptoms. The ATE of ongoing prolonged symptoms on EQ-VAS was − 12.9 [95% CI − 15.9 to − 9.8], and on the EQ-5D-3L it was − 0.11 [95% CI − 0.13 to − 0.09], implying prolonged symptoms have a negative impact on patients’ EQ-VAS and EQ-5D-3L score. In multivariable linear regression, only having prolonged symptoms was associated with lower scores (− 11.7 [95% CI − 15.0 to − 8.5] for EQ-VAS and − 0.10 [95% CI − 0.13 to − 0.08] for EQ-5D-3L). CONCLUSIONS: Due to their long duration, long-COVID symptoms represent a substantial disease burden expressed in impact on health-related quality of life. BioMed Central 2022-08-19 /pmc/articles/PMC9388960/ /pubmed/35986269 http://dx.doi.org/10.1186/s12955-022-02033-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Tsuzuki, Shinya
Miyazato, Yusuke
Terada, Mari
Morioka, Shinichiro
Ohmagari, Norio
Beutels, Philippe
Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients
title Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients
title_full Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients
title_fullStr Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients
title_full_unstemmed Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients
title_short Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients
title_sort impact of long-covid on health-related quality of life in japanese covid-19 patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388960/
https://www.ncbi.nlm.nih.gov/pubmed/35986269
http://dx.doi.org/10.1186/s12955-022-02033-6
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