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Elucidation of the tyrosinase/O(2)/monophenol ternary intermediate that dictates the monooxygenation mechanism in melanin biosynthesis

Melanins are highly conjugated biopolymer pigments that provide photoprotection in a wide array of organisms, from bacteria to humans. The rate-limiting step in melanin biosynthesis, which is the ortho-hydroxylation of the amino acid L-tyrosine to L-DOPA, is catalyzed by the ubiquitous enzyme tyrosi...

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Detalles Bibliográficos
Autores principales:	Kipouros, Ioannis, Stańczak, Agnieszka, Ginsbach, Jake W., Andrikopoulos, Prokopis C., Rulíšek, Lubomír, Solomon, Edward I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389030/ https://www.ncbi.nlm.nih.gov/pubmed/35939688 http://dx.doi.org/10.1073/pnas.2205619119

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