Copper deposition in Wilson’s disease causes male fertility decline by impairing reproductive hormone release through inducing apoptosis and inhibiting ERK signal in hypothalamic-pituitary of mice

Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism characterized by liver and central nervous system dysfunction. Considerable evidence suggests that infertility is also very common in male patients with WD, but the exact molecular mechanisms involved remain unknown. In or...

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Detalles Bibliográficos
Autores principales: Wang, Tingting, Wu, Limin, Chen, Qiuying, Chen, Kuiyu, Tan, Fang, Liu, Jiabo, Liu, Xiang, Han, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389053/
https://www.ncbi.nlm.nih.gov/pubmed/35992126
http://dx.doi.org/10.3389/fendo.2022.961748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389053/
https://www.ncbi.nlm.nih.gov/pubmed/35992126
http://dx.doi.org/10.3389/fendo.2022.961748

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