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Pyroptosis and inflammasomes in diabetic wound healing

Diabetic wound is one of the complications of diabetes and is not easy to heal. It often evolves into chronic ulcers, and severe patients will face amputation. Compared with normal wounds, diabetic wounds have an increased proportion of pro-inflammatory cytokines that are detrimental to the normal h...

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Autores principales: Mu, Xingrui, Wu, Xingqian, He, Wenjie, Liu, Ye, Wu, Faming, Nie, Xuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389066/
https://www.ncbi.nlm.nih.gov/pubmed/35992142
http://dx.doi.org/10.3389/fendo.2022.950798
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author Mu, Xingrui
Wu, Xingqian
He, Wenjie
Liu, Ye
Wu, Faming
Nie, Xuqiang
author_facet Mu, Xingrui
Wu, Xingqian
He, Wenjie
Liu, Ye
Wu, Faming
Nie, Xuqiang
author_sort Mu, Xingrui
collection PubMed
description Diabetic wound is one of the complications of diabetes and is not easy to heal. It often evolves into chronic ulcers, and severe patients will face amputation. Compared with normal wounds, diabetic wounds have an increased proportion of pro-inflammatory cytokines that are detrimental to the normal healing response. The burden of this disease on patients and healthcare providers is overwhelming, and practical solutions for managing and treating diabetic wounds are urgently needed. Pyroptosis, an inflammatory type of programmed cell death, is usually triggered by the inflammasome. The pyroptosis-driven cell death process is primarily mediated by the traditional signaling pathway caused by caspase -1 and the non-classical signaling pathways induced by caspase -4/5/11. Growing evidence that pyroptosis promotes diabetic complications, including diabetic wounds. In addition, inflammation is thought to be detrimental to wound healing. It is worth noting that the activation of the NLRP3 inflammasome plays a crucial role in the recovery of diabetic wounds. This review has described the mechanisms of pyroptosis-related signaling pathways and their impact on diabetic wounds. It has discussed new theories and approaches to promote diabetic wound healing, as well as some potential compounds targeting pyroptosis and inflammasome signaling pathways that could be new approaches to treating diabetic wounds.
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spelling pubmed-93890662022-08-20 Pyroptosis and inflammasomes in diabetic wound healing Mu, Xingrui Wu, Xingqian He, Wenjie Liu, Ye Wu, Faming Nie, Xuqiang Front Endocrinol (Lausanne) Endocrinology Diabetic wound is one of the complications of diabetes and is not easy to heal. It often evolves into chronic ulcers, and severe patients will face amputation. Compared with normal wounds, diabetic wounds have an increased proportion of pro-inflammatory cytokines that are detrimental to the normal healing response. The burden of this disease on patients and healthcare providers is overwhelming, and practical solutions for managing and treating diabetic wounds are urgently needed. Pyroptosis, an inflammatory type of programmed cell death, is usually triggered by the inflammasome. The pyroptosis-driven cell death process is primarily mediated by the traditional signaling pathway caused by caspase -1 and the non-classical signaling pathways induced by caspase -4/5/11. Growing evidence that pyroptosis promotes diabetic complications, including diabetic wounds. In addition, inflammation is thought to be detrimental to wound healing. It is worth noting that the activation of the NLRP3 inflammasome plays a crucial role in the recovery of diabetic wounds. This review has described the mechanisms of pyroptosis-related signaling pathways and their impact on diabetic wounds. It has discussed new theories and approaches to promote diabetic wound healing, as well as some potential compounds targeting pyroptosis and inflammasome signaling pathways that could be new approaches to treating diabetic wounds. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389066/ /pubmed/35992142 http://dx.doi.org/10.3389/fendo.2022.950798 Text en Copyright © 2022 Mu, Wu, He, Liu, Wu and Nie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Mu, Xingrui
Wu, Xingqian
He, Wenjie
Liu, Ye
Wu, Faming
Nie, Xuqiang
Pyroptosis and inflammasomes in diabetic wound healing
title Pyroptosis and inflammasomes in diabetic wound healing
title_full Pyroptosis and inflammasomes in diabetic wound healing
title_fullStr Pyroptosis and inflammasomes in diabetic wound healing
title_full_unstemmed Pyroptosis and inflammasomes in diabetic wound healing
title_short Pyroptosis and inflammasomes in diabetic wound healing
title_sort pyroptosis and inflammasomes in diabetic wound healing
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389066/
https://www.ncbi.nlm.nih.gov/pubmed/35992142
http://dx.doi.org/10.3389/fendo.2022.950798
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