Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders

OBJECTIVES: We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values and neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Piao, Chen, Junling, Cai, Tongtong, He, Chentao, Li, Yan, Li, Xiaohong, Chen, Zhenzhen, Wang, Lijuan, Zhang, Yuhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389149/
https://www.ncbi.nlm.nih.gov/pubmed/35992605
http://dx.doi.org/10.3389/fnagi.2022.909552
_version_ 1784770376493957120
author Zhang, Piao
Chen, Junling
Cai, Tongtong
He, Chentao
Li, Yan
Li, Xiaohong
Chen, Zhenzhen
Wang, Lijuan
Zhang, Yuhu
author_facet Zhang, Piao
Chen, Junling
Cai, Tongtong
He, Chentao
Li, Yan
Li, Xiaohong
Chen, Zhenzhen
Wang, Lijuan
Zhang, Yuhu
author_sort Zhang, Piao
collection PubMed
description OBJECTIVES: We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values and neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). MATERIALS AND METHODS: Forty-seven patients with PD, 28 patients with MSA, 18 patients with PSP, and 28 healthy controls (HC) were enrolled, and QSM data were reconstructed. Susceptibility values in the bilateral globus pallidus (GP), putamen (PUT), caudate nucleus (CN), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN) were obtained. Plasma NfL levels of 47 PD, 18 MSA, and 14 PSP patients and 22 HC were measured by ultrasensitive Simoa technology. RESULTS: The highest diagnostic accuracy distinguishing MSA from PD patients was observed with increased susceptibility values in CN (AUC: 0.740). The susceptibility values in RN yielded the highest diagnostic performance for distinguishing PSP from PD patients (AUC: 0.829). Plasma NfL levels were significantly higher in the MSA and PSP groups than in PD and HC groups. Combining the susceptibility values in the RN and plasma NfL levels improved the diagnostic performance for PSP vs. PD (AUC: 0.904), whereas plasma NfL levels had higher diagnostic accuracy for MSA vs. PD (AUC: 0.877). CONCLUSION: The exploratory study indicates different patterns of iron accumulation in deep gray matter nuclei in Parkinsonian disorders. Combining QSM values with NfL levels may be a promising biomarker for distinguishing PSP from PD, whereas plasma NfL may be a reliable biomarker for differentiating MSA from PD. QSM and NfL measures appeared to have low accuracy for separating PD from controls.
format Online
Article
Text
id pubmed-9389149
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93891492022-08-20 Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders Zhang, Piao Chen, Junling Cai, Tongtong He, Chentao Li, Yan Li, Xiaohong Chen, Zhenzhen Wang, Lijuan Zhang, Yuhu Front Aging Neurosci Neuroscience OBJECTIVES: We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values and neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). MATERIALS AND METHODS: Forty-seven patients with PD, 28 patients with MSA, 18 patients with PSP, and 28 healthy controls (HC) were enrolled, and QSM data were reconstructed. Susceptibility values in the bilateral globus pallidus (GP), putamen (PUT), caudate nucleus (CN), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN) were obtained. Plasma NfL levels of 47 PD, 18 MSA, and 14 PSP patients and 22 HC were measured by ultrasensitive Simoa technology. RESULTS: The highest diagnostic accuracy distinguishing MSA from PD patients was observed with increased susceptibility values in CN (AUC: 0.740). The susceptibility values in RN yielded the highest diagnostic performance for distinguishing PSP from PD patients (AUC: 0.829). Plasma NfL levels were significantly higher in the MSA and PSP groups than in PD and HC groups. Combining the susceptibility values in the RN and plasma NfL levels improved the diagnostic performance for PSP vs. PD (AUC: 0.904), whereas plasma NfL levels had higher diagnostic accuracy for MSA vs. PD (AUC: 0.877). CONCLUSION: The exploratory study indicates different patterns of iron accumulation in deep gray matter nuclei in Parkinsonian disorders. Combining QSM values with NfL levels may be a promising biomarker for distinguishing PSP from PD, whereas plasma NfL may be a reliable biomarker for differentiating MSA from PD. QSM and NfL measures appeared to have low accuracy for separating PD from controls. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389149/ /pubmed/35992605 http://dx.doi.org/10.3389/fnagi.2022.909552 Text en Copyright © 2022 Zhang, Chen, Cai, He, Li, Li, Chen, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Piao
Chen, Junling
Cai, Tongtong
He, Chentao
Li, Yan
Li, Xiaohong
Chen, Zhenzhen
Wang, Lijuan
Zhang, Yuhu
Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
title Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
title_full Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
title_fullStr Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
title_full_unstemmed Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
title_short Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
title_sort quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389149/
https://www.ncbi.nlm.nih.gov/pubmed/35992605
http://dx.doi.org/10.3389/fnagi.2022.909552
work_keys_str_mv AT zhangpiao quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT chenjunling quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT caitongtong quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT hechentao quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT liyan quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT lixiaohong quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT chenzhenzhen quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT wanglijuan quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders
AT zhangyuhu quantitativesusceptibilitymappingandbloodneurofilamentlightchaindifferentiatebetweenparkinsoniandisorders