Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders
OBJECTIVES: We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values and neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389149/ https://www.ncbi.nlm.nih.gov/pubmed/35992605 http://dx.doi.org/10.3389/fnagi.2022.909552 |
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author | Zhang, Piao Chen, Junling Cai, Tongtong He, Chentao Li, Yan Li, Xiaohong Chen, Zhenzhen Wang, Lijuan Zhang, Yuhu |
author_facet | Zhang, Piao Chen, Junling Cai, Tongtong He, Chentao Li, Yan Li, Xiaohong Chen, Zhenzhen Wang, Lijuan Zhang, Yuhu |
author_sort | Zhang, Piao |
collection | PubMed |
description | OBJECTIVES: We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values and neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). MATERIALS AND METHODS: Forty-seven patients with PD, 28 patients with MSA, 18 patients with PSP, and 28 healthy controls (HC) were enrolled, and QSM data were reconstructed. Susceptibility values in the bilateral globus pallidus (GP), putamen (PUT), caudate nucleus (CN), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN) were obtained. Plasma NfL levels of 47 PD, 18 MSA, and 14 PSP patients and 22 HC were measured by ultrasensitive Simoa technology. RESULTS: The highest diagnostic accuracy distinguishing MSA from PD patients was observed with increased susceptibility values in CN (AUC: 0.740). The susceptibility values in RN yielded the highest diagnostic performance for distinguishing PSP from PD patients (AUC: 0.829). Plasma NfL levels were significantly higher in the MSA and PSP groups than in PD and HC groups. Combining the susceptibility values in the RN and plasma NfL levels improved the diagnostic performance for PSP vs. PD (AUC: 0.904), whereas plasma NfL levels had higher diagnostic accuracy for MSA vs. PD (AUC: 0.877). CONCLUSION: The exploratory study indicates different patterns of iron accumulation in deep gray matter nuclei in Parkinsonian disorders. Combining QSM values with NfL levels may be a promising biomarker for distinguishing PSP from PD, whereas plasma NfL may be a reliable biomarker for differentiating MSA from PD. QSM and NfL measures appeared to have low accuracy for separating PD from controls. |
format | Online Article Text |
id | pubmed-9389149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93891492022-08-20 Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders Zhang, Piao Chen, Junling Cai, Tongtong He, Chentao Li, Yan Li, Xiaohong Chen, Zhenzhen Wang, Lijuan Zhang, Yuhu Front Aging Neurosci Neuroscience OBJECTIVES: We employed quantitative susceptibility mapping (QSM) to assess iron deposition in parkinsonian disorders and explored whether combining QSM values and neurofilament light (NfL) chain levels can improve the accuracy of distinguishing Parkinson’s disease (PD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). MATERIALS AND METHODS: Forty-seven patients with PD, 28 patients with MSA, 18 patients with PSP, and 28 healthy controls (HC) were enrolled, and QSM data were reconstructed. Susceptibility values in the bilateral globus pallidus (GP), putamen (PUT), caudate nucleus (CN), red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN) were obtained. Plasma NfL levels of 47 PD, 18 MSA, and 14 PSP patients and 22 HC were measured by ultrasensitive Simoa technology. RESULTS: The highest diagnostic accuracy distinguishing MSA from PD patients was observed with increased susceptibility values in CN (AUC: 0.740). The susceptibility values in RN yielded the highest diagnostic performance for distinguishing PSP from PD patients (AUC: 0.829). Plasma NfL levels were significantly higher in the MSA and PSP groups than in PD and HC groups. Combining the susceptibility values in the RN and plasma NfL levels improved the diagnostic performance for PSP vs. PD (AUC: 0.904), whereas plasma NfL levels had higher diagnostic accuracy for MSA vs. PD (AUC: 0.877). CONCLUSION: The exploratory study indicates different patterns of iron accumulation in deep gray matter nuclei in Parkinsonian disorders. Combining QSM values with NfL levels may be a promising biomarker for distinguishing PSP from PD, whereas plasma NfL may be a reliable biomarker for differentiating MSA from PD. QSM and NfL measures appeared to have low accuracy for separating PD from controls. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389149/ /pubmed/35992605 http://dx.doi.org/10.3389/fnagi.2022.909552 Text en Copyright © 2022 Zhang, Chen, Cai, He, Li, Li, Chen, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Piao Chen, Junling Cai, Tongtong He, Chentao Li, Yan Li, Xiaohong Chen, Zhenzhen Wang, Lijuan Zhang, Yuhu Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
title | Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
title_full | Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
title_fullStr | Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
title_full_unstemmed | Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
title_short | Quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
title_sort | quantitative susceptibility mapping and blood neurofilament light chain differentiate between parkinsonian disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389149/ https://www.ncbi.nlm.nih.gov/pubmed/35992605 http://dx.doi.org/10.3389/fnagi.2022.909552 |
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