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Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis
Inhibitory control (IC) is a fundamental cognitive function showing age-related change across the healthy lifespan. Since different cognitive resources are needed in the two subcomponents of IC (cognitive inhibition and response inhibition), regions of the brain are differentially activated. In this...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389163/ https://www.ncbi.nlm.nih.gov/pubmed/35992590 http://dx.doi.org/10.3389/fnagi.2022.938789 |
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author | Long, Jixin Song, Xiaoqi Wang, You Wang, Chanyu Huang, Ruiwang Zhang, Ruibin |
author_facet | Long, Jixin Song, Xiaoqi Wang, You Wang, Chanyu Huang, Ruiwang Zhang, Ruibin |
author_sort | Long, Jixin |
collection | PubMed |
description | Inhibitory control (IC) is a fundamental cognitive function showing age-related change across the healthy lifespan. Since different cognitive resources are needed in the two subcomponents of IC (cognitive inhibition and response inhibition), regions of the brain are differentially activated. In this study, we aimed to determine whether there is a distinct age-related activation pattern in these two subcomponents. A total of 278 fMRI articles were included in the current analysis. Multilevel kernel density analysis was used to provide data on brain activation under each subcomponent of IC. Contrast analyses were conducted to capture the distinct activated brain regions for the two subcomponents, whereas meta-regression analyses were performed to identify brain regions with distinct age-related activation patterns in the two subcomponents of IC. The results showed that the right inferior frontal gyrus and the bilateral insula were activated during the two IC subcomponents. Contrast analyses revealed stronger activation in the superior parietal lobule during cognitive inhibition, whereas stronger activation during response inhibition was observed primarily in the right inferior frontal gyrus, bilateral insula, and angular gyrus. Furthermore, regression analyses showed that activation of the left anterior cingulate cortex, left inferior frontal gyrus, bilateral insula, and left superior parietal lobule increased and decreased with age during cognitive inhibition and response inhibition, respectively. The results showed distinct activation patterns of aging for the two subcomponents of IC, which may be related to the differential cognitive resources recruited. These findings may help to enhance knowledge of age-related changes in the activation patterns of IC. |
format | Online Article Text |
id | pubmed-9389163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93891632022-08-20 Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis Long, Jixin Song, Xiaoqi Wang, You Wang, Chanyu Huang, Ruiwang Zhang, Ruibin Front Aging Neurosci Neuroscience Inhibitory control (IC) is a fundamental cognitive function showing age-related change across the healthy lifespan. Since different cognitive resources are needed in the two subcomponents of IC (cognitive inhibition and response inhibition), regions of the brain are differentially activated. In this study, we aimed to determine whether there is a distinct age-related activation pattern in these two subcomponents. A total of 278 fMRI articles were included in the current analysis. Multilevel kernel density analysis was used to provide data on brain activation under each subcomponent of IC. Contrast analyses were conducted to capture the distinct activated brain regions for the two subcomponents, whereas meta-regression analyses were performed to identify brain regions with distinct age-related activation patterns in the two subcomponents of IC. The results showed that the right inferior frontal gyrus and the bilateral insula were activated during the two IC subcomponents. Contrast analyses revealed stronger activation in the superior parietal lobule during cognitive inhibition, whereas stronger activation during response inhibition was observed primarily in the right inferior frontal gyrus, bilateral insula, and angular gyrus. Furthermore, regression analyses showed that activation of the left anterior cingulate cortex, left inferior frontal gyrus, bilateral insula, and left superior parietal lobule increased and decreased with age during cognitive inhibition and response inhibition, respectively. The results showed distinct activation patterns of aging for the two subcomponents of IC, which may be related to the differential cognitive resources recruited. These findings may help to enhance knowledge of age-related changes in the activation patterns of IC. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389163/ /pubmed/35992590 http://dx.doi.org/10.3389/fnagi.2022.938789 Text en Copyright © 2022 Long, Song, Wang, Wang, Huang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Long, Jixin Song, Xiaoqi Wang, You Wang, Chanyu Huang, Ruiwang Zhang, Ruibin Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
title | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
title_full | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
title_fullStr | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
title_full_unstemmed | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
title_short | Distinct neural activation patterns of age in subcomponents of inhibitory control: A fMRI meta-analysis |
title_sort | distinct neural activation patterns of age in subcomponents of inhibitory control: a fmri meta-analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389163/ https://www.ncbi.nlm.nih.gov/pubmed/35992590 http://dx.doi.org/10.3389/fnagi.2022.938789 |
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