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Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis

OBJECTIVE: Aortic diseases, mainly including aortic dilatation, aortic aneurysm (AA) and aortic dissection (AD), have high morbidity and mortality. Many studies have suggested that obstructive sleep apnea (OSA) acts as a candidate risk factor for aortic diseases. Thus, we performed a meta-analysis t...

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Autores principales: Zhai, Tingting, Liu, Bilian, Zhang, Jie, Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389181/
https://www.ncbi.nlm.nih.gov/pubmed/35992006
http://dx.doi.org/10.1016/j.heliyon.2022.e10049
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author Zhai, Tingting
Liu, Bilian
Zhang, Jie
Wu, Yan
author_facet Zhai, Tingting
Liu, Bilian
Zhang, Jie
Wu, Yan
author_sort Zhai, Tingting
collection PubMed
description OBJECTIVE: Aortic diseases, mainly including aortic dilatation, aortic aneurysm (AA) and aortic dissection (AD), have high morbidity and mortality. Many studies have suggested that obstructive sleep apnea (OSA) acts as a candidate risk factor for aortic diseases. Thus, we performed a meta-analysis to explore comprehensively the effect of OSA on the risk of aortic disease occurrence. METHODS: We searched PubMed, Embase and Cochrane Library databases from inception to February 2022 to identify studies investigating the association between OSA and aortic diameter dilatation, the prevalence of OSA in individuals with or without AA/AD and the incidence of AA/AD in individuals with or without OSA. The Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) were respectively used to evaluate the quality of the included cohort and cross-sectional studies. A random or fixed effect model was used to generate pooled effects according to interstudy heterogeneity. Sensitivity analyses were performed to test the robustness of the results. RESULTS: We identified 10 observational publications with 214,127 participants in this meta-analysis. OSA was significantly associated with increased aortic diameter (WMD = 1.46, 95% CI, 1.10–1.83, p < 0.001). OSA prevalence was higher in patients with AA/AD compared to their counterparts without AA/AD (OR = 1.90, 95% CI, 1.30–2.76, p = 0.001). No significant difference in the incidence of AA/AD was observed in individuals with or without OSA (RR = 0.85, 95% CI, 0.62–1.16, p = 0.307). Sensitivity analyses did not modify these results. CONCLUSIONS: This meta-analysis suggests that OSA is associated with aortic diameter dilatation but does not affect AA/AD occurrence.
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spelling pubmed-93891812022-08-20 Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis Zhai, Tingting Liu, Bilian Zhang, Jie Wu, Yan Heliyon Research Article OBJECTIVE: Aortic diseases, mainly including aortic dilatation, aortic aneurysm (AA) and aortic dissection (AD), have high morbidity and mortality. Many studies have suggested that obstructive sleep apnea (OSA) acts as a candidate risk factor for aortic diseases. Thus, we performed a meta-analysis to explore comprehensively the effect of OSA on the risk of aortic disease occurrence. METHODS: We searched PubMed, Embase and Cochrane Library databases from inception to February 2022 to identify studies investigating the association between OSA and aortic diameter dilatation, the prevalence of OSA in individuals with or without AA/AD and the incidence of AA/AD in individuals with or without OSA. The Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) were respectively used to evaluate the quality of the included cohort and cross-sectional studies. A random or fixed effect model was used to generate pooled effects according to interstudy heterogeneity. Sensitivity analyses were performed to test the robustness of the results. RESULTS: We identified 10 observational publications with 214,127 participants in this meta-analysis. OSA was significantly associated with increased aortic diameter (WMD = 1.46, 95% CI, 1.10–1.83, p < 0.001). OSA prevalence was higher in patients with AA/AD compared to their counterparts without AA/AD (OR = 1.90, 95% CI, 1.30–2.76, p = 0.001). No significant difference in the incidence of AA/AD was observed in individuals with or without OSA (RR = 0.85, 95% CI, 0.62–1.16, p = 0.307). Sensitivity analyses did not modify these results. CONCLUSIONS: This meta-analysis suggests that OSA is associated with aortic diameter dilatation but does not affect AA/AD occurrence. Elsevier 2022-08-01 /pmc/articles/PMC9389181/ /pubmed/35992006 http://dx.doi.org/10.1016/j.heliyon.2022.e10049 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Zhai, Tingting
Liu, Bilian
Zhang, Jie
Wu, Yan
Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis
title Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis
title_full Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis
title_fullStr Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis
title_full_unstemmed Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis
title_short Impact of obstructive sleep apnea on aortic disease occurrence: A meta-analysis
title_sort impact of obstructive sleep apnea on aortic disease occurrence: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389181/
https://www.ncbi.nlm.nih.gov/pubmed/35992006
http://dx.doi.org/10.1016/j.heliyon.2022.e10049
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