ABCG2/BCRP transport mechanism revealed through kinetically excited targeted molecular dynamics simulations

ABCG2/BCRP is an ABC transporter that plays an important role in tissue protection by exporting endogenous substrates and xenobiotics. ABCG2 is of major interest due to its involvement in multidrug resistance (MDR), and understanding its complex efflux mechanism is essential to preventing MDR and dr...

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Detalles Bibliográficos
Autores principales: Dudas, B., Decleves, X., Cisternino, S., Perahia, D., Miteva, M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389183/
https://www.ncbi.nlm.nih.gov/pubmed/36016719
http://dx.doi.org/10.1016/j.csbj.2022.07.035

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