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Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion
INTRODUCTION: Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389220/ https://www.ncbi.nlm.nih.gov/pubmed/35989941 http://dx.doi.org/10.3389/fneur.2022.947524 |
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author | La Fountaine, Michael F. Hohn, Asante N. Leahy, Caroline L. Weir, Joseph P. Testa, Anthony J. |
author_facet | La Fountaine, Michael F. Hohn, Asante N. Leahy, Caroline L. Weir, Joseph P. Testa, Anthony J. |
author_sort | La Fountaine, Michael F. |
collection | PubMed |
description | INTRODUCTION: Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1) related to headache burden during the first week after concussion. METHODS: A prospective study was performed in 34 collegiate athletes who sustained a concussion. Participants completed the symptom evaluation checklist from the SCAT3 within 48 h of injury (V1), and again 4 (V2) and 7 (V3) days after injury. For each visit, the self-reported score (0–6) for headache, pressure in head, blurred vision, and sensitivity to light/noise were reported and summed to calculate the headache burden. A saliva sample was obtained and genotyped for CALCA (rs3781719) and RAMP1 (rs10185142). RAMP1 (TT, TC, CC) and CALCA (AA, AG, GG) were dichotomized (A+, A- and T+, T-, respectively), and concatenated (T+A+, T+A-, T-A+, T-A-) for analyses. RESULTS: Headache Burden at Visit 1 was greatest in T+A+ compared to T-A+, and trended toward a significant difference with T+A-. Repeated-measures ANOVA revealed the presence of significant visit main effects (p < 0.001, η(2) = 0.404), but the group (p = 0.055) and interaction effects only trended (p = 0.094). Pearson's χ(2)-tests revealed that 88% of those with return-to play (RTP) exclusions ≥15 days had PTH with multi-sensory symptoms (PTH+SENS) as compared to 35% in those with RTP < 14 day. CONCLUSION: Knowledge of RAMP1 and CALCA genotypes appear to improve an understanding the presenting features and magnitude of headache burden after concussion injury. |
format | Online Article Text |
id | pubmed-9389220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93892202022-08-20 Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion La Fountaine, Michael F. Hohn, Asante N. Leahy, Caroline L. Weir, Joseph P. Testa, Anthony J. Front Neurol Neurology INTRODUCTION: Post-traumatic headache (PTH) is commonly reported after concussion. Calcitonin gene-related peptide (CGRP) is implicated in the pathogenesis of migraine. We explored how single nucleotide polymorphisms (SNPs) from CGRP-alpha (CALCA) and the receptor activity modifying protein-1 (RAMP1) related to headache burden during the first week after concussion. METHODS: A prospective study was performed in 34 collegiate athletes who sustained a concussion. Participants completed the symptom evaluation checklist from the SCAT3 within 48 h of injury (V1), and again 4 (V2) and 7 (V3) days after injury. For each visit, the self-reported score (0–6) for headache, pressure in head, blurred vision, and sensitivity to light/noise were reported and summed to calculate the headache burden. A saliva sample was obtained and genotyped for CALCA (rs3781719) and RAMP1 (rs10185142). RAMP1 (TT, TC, CC) and CALCA (AA, AG, GG) were dichotomized (A+, A- and T+, T-, respectively), and concatenated (T+A+, T+A-, T-A+, T-A-) for analyses. RESULTS: Headache Burden at Visit 1 was greatest in T+A+ compared to T-A+, and trended toward a significant difference with T+A-. Repeated-measures ANOVA revealed the presence of significant visit main effects (p < 0.001, η(2) = 0.404), but the group (p = 0.055) and interaction effects only trended (p = 0.094). Pearson's χ(2)-tests revealed that 88% of those with return-to play (RTP) exclusions ≥15 days had PTH with multi-sensory symptoms (PTH+SENS) as compared to 35% in those with RTP < 14 day. CONCLUSION: Knowledge of RAMP1 and CALCA genotypes appear to improve an understanding the presenting features and magnitude of headache burden after concussion injury. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389220/ /pubmed/35989941 http://dx.doi.org/10.3389/fneur.2022.947524 Text en Copyright © 2022 La Fountaine, Hohn, Leahy, Weir and Testa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology La Fountaine, Michael F. Hohn, Asante N. Leahy, Caroline L. Weir, Joseph P. Testa, Anthony J. Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion |
title | Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion |
title_full | Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion |
title_fullStr | Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion |
title_full_unstemmed | Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion |
title_short | Observations from a prospective small cohort study suggest that CGRP genes contribute to acute posttraumatic headache burden after concussion |
title_sort | observations from a prospective small cohort study suggest that cgrp genes contribute to acute posttraumatic headache burden after concussion |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389220/ https://www.ncbi.nlm.nih.gov/pubmed/35989941 http://dx.doi.org/10.3389/fneur.2022.947524 |
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