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Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism

Serine hydroxymethyltransferase 2 (SHMT2), which catalyzes the conversion of serine to glycine and one-carbon transfer reactions in mitochondria, is significantly upregulated in glioblastoma (GBM). However, the mechanism by which the stability of SHMT2 gene expression is maintained to drive GBM tumo...

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Detalles Bibliográficos
Autores principales:	Han, Wei, Wang, Shanshan, Qi, Yingjiao, Wu, Fan, Tian, Ningyu, Qiang, Boqin, Peng, Xiaozhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389257/ https://www.ncbi.nlm.nih.gov/pubmed/35992092 http://dx.doi.org/10.1016/j.isci.2022.104823

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