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Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice
As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the behavior have araised. In the present study, we show for the first time that the dysregulated specific targeting of miR132 to Mmp9 mRNA in the mo...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389266/ https://www.ncbi.nlm.nih.gov/pubmed/35992198 http://dx.doi.org/10.3389/fnmol.2022.924534 |
| _version_ | 1784770406078480384 |
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| author | Kuzniewska, Bozena Rejmak, Karolina Nowacka, Agata Ziółkowska, Magdalena Milek, Jacek Magnowska, Marta Gruchota, Jakub Gewartowska, Olga Borsuk, Ewa Salamian, Ahmad Dziembowski, Andrzej Radwanska, Kasia Dziembowska, Magdalena |
| author_facet | Kuzniewska, Bozena Rejmak, Karolina Nowacka, Agata Ziółkowska, Magdalena Milek, Jacek Magnowska, Marta Gruchota, Jakub Gewartowska, Olga Borsuk, Ewa Salamian, Ahmad Dziembowski, Andrzej Radwanska, Kasia Dziembowska, Magdalena |
| author_sort | Kuzniewska, Bozena |
| collection | PubMed |
| description | As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the behavior have araised. In the present study, we show for the first time that the dysregulated specific targeting of miR132 to Mmp9 mRNA in the mouse brain results in the increased level of Mmp9 protein, which affects synaptic plasticity and has an effect on memory formation. Our data points at the importance of complex and precise regulation of the Mmp9 level by miR132 in the brain. |
| format | Online Article Text |
| id | pubmed-9389266 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93892662022-08-20 Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice Kuzniewska, Bozena Rejmak, Karolina Nowacka, Agata Ziółkowska, Magdalena Milek, Jacek Magnowska, Marta Gruchota, Jakub Gewartowska, Olga Borsuk, Ewa Salamian, Ahmad Dziembowski, Andrzej Radwanska, Kasia Dziembowska, Magdalena Front Mol Neurosci Molecular Neuroscience As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the behavior have araised. In the present study, we show for the first time that the dysregulated specific targeting of miR132 to Mmp9 mRNA in the mouse brain results in the increased level of Mmp9 protein, which affects synaptic plasticity and has an effect on memory formation. Our data points at the importance of complex and precise regulation of the Mmp9 level by miR132 in the brain. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389266/ /pubmed/35992198 http://dx.doi.org/10.3389/fnmol.2022.924534 Text en Copyright © 2022 Kuzniewska, Rejmak, Nowacka, Ziółkowska, Milek, Magnowska, Gruchota, Gewartowska, Borsuk, Salamian, Dziembowski, Radwanska and Dziembowska. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Molecular Neuroscience Kuzniewska, Bozena Rejmak, Karolina Nowacka, Agata Ziółkowska, Magdalena Milek, Jacek Magnowska, Marta Gruchota, Jakub Gewartowska, Olga Borsuk, Ewa Salamian, Ahmad Dziembowski, Andrzej Radwanska, Kasia Dziembowska, Magdalena Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice |
| title | Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice |
| title_full | Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice |
| title_fullStr | Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice |
| title_full_unstemmed | Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice |
| title_short | Disrupting interaction between miR-132 and Mmp9 3′UTR improves synaptic plasticity and memory in mice |
| title_sort | disrupting interaction between mir-132 and mmp9 3′utr improves synaptic plasticity and memory in mice |
| topic | Molecular Neuroscience |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389266/ https://www.ncbi.nlm.nih.gov/pubmed/35992198 http://dx.doi.org/10.3389/fnmol.2022.924534 |
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