Cargando…

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer

Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation of phospholipids, is associated with cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. Aspirin is a widely used non-steroidal anti-inflammatory drug (NSAID) and has be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Hao, Qi, Qinqin, Wu, Nan, Wang, Ying, Feng, Qian, Jin, Rong, Jiang, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389304/ https://www.ncbi.nlm.nih.gov/pubmed/35963119 http://dx.doi.org/10.1016/j.redox.2022.102426

Ejemplares similares

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts
por: Zhou, Zili, et al.
Publicado: (2023)

MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors: MEN1 promotes ferroptosis in pancreatic neuroendocrine tumors
por: Ye, Zeng, et al.
Publicado: (2022)

RSL3 Inhibits Porcine Epidemic Diarrhea Virus Replication by Activating Ferroptosis
por: Li, Yingguang, et al.
Publicado: (2023)

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
por: Cheff, Dorian M., et al.
Publicado: (2023)

Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells
por: Li, Shaohua, et al.
Publicado: (2015)

LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells
por: Zhou, Youping, et al.
Publicado: (2018)

Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
por: Shintoku, Ryosuke, et al.
Publicado: (2017)

Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab
por: Liu, Shujie, et al.
Publicado: (2022)

The ferroptosis inducer RSL3 triggers interictal epileptiform activity in mice cortical neurons
por: Giustizieri, Michela, et al.
Publicado: (2023)

Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 against Toxoplasma gondii
por: Huang, Mao, et al.
Publicado: (2022)

Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
por: Zhao, Qiushi, et al.
Publicado: (2022)

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
por: Sui, Xinbing, et al.
Publicado: (2018)

Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer
por: Wang, Ying, et al.
Publicado: (2022)

Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells
por: Li, Ling, et al.
Publicado: (2019)

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
por: Chen, Yaqing, et al.
Publicado: (2016)

Platelet-Vesicles-Encapsulated RSL-3 Enable Anti-Angiogenesis and Induce Ferroptosis to Inhibit Pancreatic Cancer Progress
por: Zhang, Yiyin, et al.
Publicado: (2022)

RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma
por: Li, Shengbiao, et al.
Publicado: (2021)

Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer
por: Maccarinelli, Federica, et al.
Publicado: (2023)

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis
por: Kim, Joo-Won, et al.
Publicado: (2023)

The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS)
por: Suzuki, Yasuyo, et al.
Publicado: (2017)

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer
por: Yang, Jiawen, et al.
Publicado: (2021)

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
por: Viscarra, Jose A., et al.
Publicado: (2020)

Oncogenic signaling upstream of mTORC1 drives lipogenesis and proliferation through SREBP
por: Ricoult, Stéphane, et al.
Publicado: (2014)

GPR41 Regulates the Proliferation of BRECs via the PIK3-AKT-mTOR Pathway
por: Meng, Zitong, et al.
Publicado: (2023)

Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells
por: Zhou, Bing-rong, et al.
Publicado: (2012)

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
por: Zhou, Jian, et al.
Publicado: (2019)

O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancer
por: Zhu, Guoqing, et al.
Publicado: (2021)

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy
por: Talebi, Ali, et al.
Publicado: (2018)

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumor growth
por: Cheng, Chunming, et al.
Publicado: (2022)

Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway
por: Lin, Yen-Chung, et al.
Publicado: (2019)

Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila
por: Li, Xiao, et al.
Publicado: (2022)

PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging
por: Duggan, Michael R., et al.
Publicado: (2021)

Th-POK regulates mammary gland lactation through mTOR-SREBP pathway
por: Zhang, Rui, et al.
Publicado: (2018)

The RSL3 Induction of KLK Lung Adenocarcinoma Cell Ferroptosis by Inhibition of USP11 Activity and the NRF2-GSH Axis
por: Zhang, Wenlong, et al.
Publicado: (2022)

Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells
por: Campbell, Taaliah, et al.
Publicado: (2023)

SCD1 deficiency exacerbates osteoarthritis by inducing ferroptosis in chondrocytes
por: Yu, Chao, et al.
Publicado: (2023)

Le RSL au CERN
Publicado: (1998)

SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway: SREBP2 Inhibitor sensitizes HCC to lenvatinib
por: Fan, Minghao, et al.
Publicado: (2023)

The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis
por: Wang, Yongjia, et al.
Publicado: (2022)

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice
por: Linden, Albert G., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c37re9dfdof53ohfij3t9l7olf