Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE

Phospholipid peroxidation of polyunsaturated fatty acids at the bis-allylic position drives ferroptosis. Here we identify a novel role for phospholipid peroxidation in the inhibition of autophagy. Using in vitro and in vivo models, we report that phospholipid peroxidation induced by glutathione pero...

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Detalles Bibliográficos
Autores principales: Li, Wen, Luo, Lian-Xiang, Zhou, Qing-Qing, Gong, Hai-Biao, Fu, Yuan-Yuan, Yan, Chang-Yu, Li, E., Sun, Jie, Luo, Zhuo, Ding, Zhao-Jun, Zhang, Qiong-Yi, Mu, Han-Lu, Cao, Yun-Feng, Ouyang, Shu-Hua, Kurihara, Hiroshi, Li, Yi-Fang, Sun, Wan-Yang, Li, Min, He, Rong-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389305/
https://www.ncbi.nlm.nih.gov/pubmed/35964342
http://dx.doi.org/10.1016/j.redox.2022.102421

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