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A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy

Gastric cancer (GC) is the third-leading cause of cancer mortality worldwide. The aim of this study was to develop a nomogram that estimates 1-year, 3-year, and 5-year survival probability of GC patients after D2 gastrectomy combined with adjuvant chemotherapy. The results showed that median age is...

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Autores principales: Ma, Ling, Chen, Guosheng, Wang, Deqiang, Zhang, Kai, Zhao, Fengjiao, Tang, Jie, Zhao, Jianyi, Røe, Oluf Dimitri, He, Shaohua, Liao, Dongcheng, Gu, Yanhong, Tao, Min, Shu, Yongqian, Li, Wei, Chen, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389342/
https://www.ncbi.nlm.nih.gov/pubmed/35992865
http://dx.doi.org/10.3389/fonc.2022.893998
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author Ma, Ling
Chen, Guosheng
Wang, Deqiang
Zhang, Kai
Zhao, Fengjiao
Tang, Jie
Zhao, Jianyi
Røe, Oluf Dimitri
He, Shaohua
Liao, Dongcheng
Gu, Yanhong
Tao, Min
Shu, Yongqian
Li, Wei
Chen, Xiaofeng
author_facet Ma, Ling
Chen, Guosheng
Wang, Deqiang
Zhang, Kai
Zhao, Fengjiao
Tang, Jie
Zhao, Jianyi
Røe, Oluf Dimitri
He, Shaohua
Liao, Dongcheng
Gu, Yanhong
Tao, Min
Shu, Yongqian
Li, Wei
Chen, Xiaofeng
author_sort Ma, Ling
collection PubMed
description Gastric cancer (GC) is the third-leading cause of cancer mortality worldwide. The aim of this study was to develop a nomogram that estimates 1-year, 3-year, and 5-year survival probability of GC patients after D2 gastrectomy combined with adjuvant chemotherapy. The results showed that median age is 58 (range: 18-85) years in the training cohort and 59 (range: 32-85) years in the validation cohort. On multivariate analysis, four factors were found to be significantly associated with worse overall survival (OS): late TNM stage, positive resection margin, preoperative carcinoembryonic antigen (CEA) level, and single chemotherapy regimens compared with multiple chemotherapy regimens. All of these findings were validated in the validation cohort. Furthermore, the four factors were included in the final nomogram for the prediction of 1-year, 3-year, and 5-year survival probability, with accurate calibration and reasonable discrimination (C-index = 0.676 for training cohort, and C-index = 0.664 for validation cohort). The AUC values analyzed by the ROC analysis demonstrated a good predictive accuracy of the nomogram for OS (1-year, 3-year, and 5-year OS were 94.43%, 77.42%, and 73.03% in the training cohort, respectively; 96.95%, 81.54%, and 73.41% in the validation cohort, respectively). In conclusion, the proposed nomogram may be used to objectively and accurately predict survival probability of GC patients in a multi-institutional clinical setting.
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spelling pubmed-93893422022-08-20 A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy Ma, Ling Chen, Guosheng Wang, Deqiang Zhang, Kai Zhao, Fengjiao Tang, Jie Zhao, Jianyi Røe, Oluf Dimitri He, Shaohua Liao, Dongcheng Gu, Yanhong Tao, Min Shu, Yongqian Li, Wei Chen, Xiaofeng Front Oncol Oncology Gastric cancer (GC) is the third-leading cause of cancer mortality worldwide. The aim of this study was to develop a nomogram that estimates 1-year, 3-year, and 5-year survival probability of GC patients after D2 gastrectomy combined with adjuvant chemotherapy. The results showed that median age is 58 (range: 18-85) years in the training cohort and 59 (range: 32-85) years in the validation cohort. On multivariate analysis, four factors were found to be significantly associated with worse overall survival (OS): late TNM stage, positive resection margin, preoperative carcinoembryonic antigen (CEA) level, and single chemotherapy regimens compared with multiple chemotherapy regimens. All of these findings were validated in the validation cohort. Furthermore, the four factors were included in the final nomogram for the prediction of 1-year, 3-year, and 5-year survival probability, with accurate calibration and reasonable discrimination (C-index = 0.676 for training cohort, and C-index = 0.664 for validation cohort). The AUC values analyzed by the ROC analysis demonstrated a good predictive accuracy of the nomogram for OS (1-year, 3-year, and 5-year OS were 94.43%, 77.42%, and 73.03% in the training cohort, respectively; 96.95%, 81.54%, and 73.41% in the validation cohort, respectively). In conclusion, the proposed nomogram may be used to objectively and accurately predict survival probability of GC patients in a multi-institutional clinical setting. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9389342/ /pubmed/35992865 http://dx.doi.org/10.3389/fonc.2022.893998 Text en Copyright © 2022 Ma, Chen, Wang, Zhang, Zhao, Tang, Zhao, Røe, He, Liao, Gu, Tao, Shu, Li and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ma, Ling
Chen, Guosheng
Wang, Deqiang
Zhang, Kai
Zhao, Fengjiao
Tang, Jie
Zhao, Jianyi
Røe, Oluf Dimitri
He, Shaohua
Liao, Dongcheng
Gu, Yanhong
Tao, Min
Shu, Yongqian
Li, Wei
Chen, Xiaofeng
A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
title A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
title_full A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
title_fullStr A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
title_full_unstemmed A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
title_short A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
title_sort nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389342/
https://www.ncbi.nlm.nih.gov/pubmed/35992865
http://dx.doi.org/10.3389/fonc.2022.893998
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