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Case report: A colorectal cancer patient with microsatellite instability-high and MSH2 germline mutation failed to respond to anti-PD-1 immunotherapy

Lynch syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes. In colorectal cancer (CRC), germline mutations of DNA MMR genes commonly lead to microsatellite instability-high (MSI-H) subtype formation. Recent studies have demonstrated that CRC patients with MSI-H...

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Detalles Bibliográficos
Autores principales:	Zhang, Qun, Hu, Jing, Zhang, Yaping, Li, Li, Wang, Ting, Qian, Xiaoping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389357/ https://www.ncbi.nlm.nih.gov/pubmed/35990637 http://dx.doi.org/10.3389/fimmu.2022.953421

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