Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status

MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and MDM4 interact via their RING domains and form a heterodimer polyubiquitin E3 ligase essential for p53 degradation. MDM4 also forms heterodimer E3 ligases with MDM2 isoforms that lack p53-binding domains, which regul...

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Detalles Bibliográficos
Autores principales: Lama, Rati, Xu, Chao, Galster, Samuel L., Querol-García, Javier, Portwood, Scott, Mavis, Cory K., Ruiz, Federico M., Martin, Diana, Wu, Jin, Giorgi, Marianna C., Bargonetti, Jill, Wang, Eunice S., Hernandez-Ilizaliturri, Francisco J., Koudelka, Gerald B., Chemler, Sherry R., Muñoz, Inés G., Wang, Xinjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389462/
https://www.ncbi.nlm.nih.gov/pubmed/35992795
http://dx.doi.org/10.3389/fonc.2022.933446

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