SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8(+) T-cells

Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8(+) cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral therapy (ART)-treated individuals have shown increases in HIV transcription, but without reductions in virologic...

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Detalles Bibliográficos
Autores principales: Stevenson, Eva M., Terry, Sandra, Copertino, Dennis, Leyre, Louise, Danesh, Ali, Weiler, Jared, Ward, Adam R., Khadka, Pragya, McNeil, Evan, Bernard, Kevin, Miller, Itzayana G., Ellsworth, Grant B., Johnston, Carrie D., Finkelsztein, Eli J., Zumbo, Paul, Betel, Doron, Dündar, Friederike, Duncan, Maggie C., Lapointe, Hope R., Speckmaier, Sarah, Moran-Garcia, Nadia, Papa, Michelle Premazzi, Nicholes, Samuel, Stover, Carissa J., Lynch, Rebecca M., Caskey, Marina, Gaebler, Christian, Chun, Tae-Wook, Bosque, Alberto, Wilkin, Timothy J., Lee, Guinevere Q., Brumme, Zabrina L., Jones, R. Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389512/
https://www.ncbi.nlm.nih.gov/pubmed/35985993
http://dx.doi.org/10.1038/s41467-022-32376-z

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