1,6-epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

[Image: see text] α-Glucosidase inhibitors are potential therapeutics for the treatment of diabetes, viral infections, and Pompe disease. Herein, we report a 1,6-epi-cyclophellitol cyclosulfamidate as a new class of reversible α-glucosidase inhibitors that displays enzyme inhibitory activity by virt...

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Detalles Bibliográficos
Autores principales: Kok, Ken, Kuo, Chi-Lin, Katzy, Rebecca E., Lelieveld, Lindsey T., Wu, Liang, Roig-Zamboni, Véronique, van der Marel, Gijsbert A., Codée, Jeroen D. C., Sulzenbacher, Gerlind, Davies, Gideon J., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389588/
https://www.ncbi.nlm.nih.gov/pubmed/35917590
http://dx.doi.org/10.1021/jacs.2c05666

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