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Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH

[Image: see text] Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to the disulfide GSSG. The cytosolic GSH/GSSG ratio is very high (>100), and its reduction can lead...

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Detalles Bibliográficos
Autores principales:	Falcone, Enrico, Ritacca, Alessandra G., Hager, Sonja, Schueffl, Hemma, Vileno, Bertrand, El Khoury, Youssef, Hellwig, Petra, Kowol, Christian R., Heffeter, Petra, Sicilia, Emilia, Faller, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389589/ https://www.ncbi.nlm.nih.gov/pubmed/35929814 http://dx.doi.org/10.1021/jacs.2c05355

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