Cargando…

Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies

[Image: see text] Aβ oligomers play a central role in the neurodegeneration observed with Alzheimer’s disease. Our laboratory has developed covalently stabilized trimers derived from residues 17–36 of Aβ as model systems for studying Aβ oligomers. In the current study, we apply the emerging techniqu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guaglianone, Gretchen, Torrado, Belén, Lin, Yu-Fu, Watkins, Matthew C., Wysocki, Vicki H., Gratton, Enrico, Nowick, James S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389591/ https://www.ncbi.nlm.nih.gov/pubmed/35892278 http://dx.doi.org/10.1021/acschemneuro.2c00313

Ejemplares similares

Probing differences among Aβ oligomers with two triangular trimers derived from Aβ
por: Kreutzer, Adam G., et al.
Publicado: (2023)

X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ(17–36)
por: Spencer, Ryan K., et al.
Publicado: (2014)

An Organic Chemist’s Guide to Electrospray Mass Spectrometric Structure Elucidation
por: Steckel, Arnold, et al.
Publicado: (2019)

Mass spectrometric investigations of the action of hypochlorous acid on monomeric and oligomeric components of glycosaminoglycans
por: Leopold, Jenny, et al.
Publicado: (2023)

Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives
por: Jones, Chelsea R., et al.
Publicado: (2022)

Structure elucidation of metabolite x17299 by interpretation of mass spectrometric data
por: Zhang, Qibo, et al.
Publicado: (2017)

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ
por: Kreutzer, Adam G., et al.
Publicado: (2016)

Pyrene-Functionalized Fluorescent Nanojars: Synthesis, Mass Spectrometric, and Photophysical Studies
por: Mitchell, Melanie M., et al.
Publicado: (2021)

Posttranslational oligomerization and cooperative acid activation of mixed influenza hemagglutinin trimers
Publicado: (1988)

In silico and in vitro metabolism of ribociclib: a mass spectrometric approach to bioactivation pathway elucidation and metabolite profiling
por: Alsubi, Thamer A., et al.
Publicado: (2020)

Oligomerization of the SARS-CoV S glycoprotein: dimerization of the N-terminus and trimerization of the ectodomain
por: Xiao, Xiaodong, et al.
Publicado: (2004)

Correction: In silico and in vitro metabolism of ribociclib: a mass spectrometric approach to bioactivation pathway elucidation and metabolite profiling
por: Alsubi, Thamer A., et al.
Publicado: (2020)

Mass Spectrometric Proteomics 2022
por: Iadarola, Paolo
Publicado: (2022)

Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro
por: Kittilä, Tiia, et al.
Publicado: (2022)

Spatiotemporal regulation of Heterochromatin Protein 1- alpha oligomerization and dynamics in live cells
por: Hinde, Elizabeth, et al.
Publicado: (2015)

X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ(17–36) β-Hairpin
por: Kreutzer, Adam G., et al.
Publicado: (2016)

A small azide-modified thiazole-based reporter molecule for fluorescence and mass spectrometric detection
por: Wolfram, Stefanie, et al.
Publicado: (2014)

Structural Expansion of Catalytic RNA Nanostructures through Oligomerization of a Cyclic Trimer of Engineered Ribozymes
por: Siddika, Mst. Ayesha, et al.
Publicado: (2023)

X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers
por: Salveson, Patrick J., et al.
Publicado: (2016)

Mass Spectrometric Analysis of Glycosphingolipid Antigens
por: Yin, Alexandra Bili, et al.
Publicado: (2013)

Special Issue: Mass Spectrometric Proteomics
por: Iadarola, Paolo
Publicado: (2019)

Mass spectrometric snapshots for electrochemical reactions
por: Qiu, Ran, et al.
Publicado: (2016)

Mass spectrometric insights into protein aggregation
por: Pukala, Tara L.
Publicado: (2023)

A cyclic peptide inhibitor of the SARS-CoV-2 main protease
por: Kreutzer, Adam G., et al.
Publicado: (2021)

Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53 in Vivo
por: Chen, Eric S.-W., et al.
Publicado: (2014)

Single-molecule fluorescence-based analysis of protein conformation, interaction, and oligomerization in cellular systems
por: Okamoto, Kenji, et al.
Publicado: (2017)

Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins
por: Purde, Vedud, et al.
Publicado: (2019)

Thermodynamic coupling between neighboring binding sites in homo‐oligomeric ligand sensing proteins from mass resolved ligand‐dependent population distributions
por: Li, Weicheng, et al.
Publicado: (2022)

Mass spectrometric analysis of protein–ligand interactions
por: Ishii, Kentaro, et al.
Publicado: (2016)

Direct mass spectrometric characterization of disulfide linkages
por: Guan, Xiaoyan, et al.
Publicado: (2018)

Mass Spectrometric Characterization of Epoxidized Vegetable Oils
por: Kuki, Ákos, et al.
Publicado: (2019)

Application of Three-Photon Excitation FCS to the Study of Protein Oligomerization
por: Ranjit, Suman, et al.
Publicado: (2014)

Fluorescence Spectrometric Determination of Nonfluorescent Compounds via Molecular Fragmentation
por: Wehry, E. L.
Publicado: (1988)

Comparison of in vitro and in vivo oligomeric states of a wild type and mutant trimeric inner membrane multidrug transporter
por: Wang, Zhaoshuai, et al.
Publicado: (2018)

Mass Spectrometric Evaluation of β-Cyclodextrins as Potential Hosts for Titanocene Dichloride
por: Bruni, Pia S., et al.
Publicado: (2021)

Linear Combination Properties of the Phasor Space in Fluorescence Imaging
por: Torrado, Belén, et al.
Publicado: (2022)

Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH
por: Stringari, Chiara, et al.
Publicado: (2012)

Mass spectrometric analysis of tobacco-specific hemoglobin adducts.
por: Schäffler, G, et al.
Publicado: (1993)

Mass Spectrometric Analysis of Multiple Pertussis Toxins and Toxoids
por: Williamson, Yulanda M., et al.
Publicado: (2010)

Automated mass spectrometric analysis of urinary and plasma serotonin
por: de Jong, Wilhelmina H. A., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_oph6kbufa0dlvs1d9ui7qe2evd