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Insular functional connectivity in migraine with aura

INTRODUCTION: Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related...

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Autores principales: Gollion, Cédric, Lerebours, Fleur, Nemmi, Federico, Arribarat, Germain, Bonneville, Fabrice, Larrue, Vincent, Péran, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389744/
https://www.ncbi.nlm.nih.gov/pubmed/35982396
http://dx.doi.org/10.1186/s10194-022-01473-1
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author Gollion, Cédric
Lerebours, Fleur
Nemmi, Federico
Arribarat, Germain
Bonneville, Fabrice
Larrue, Vincent
Péran, Patrice
author_facet Gollion, Cédric
Lerebours, Fleur
Nemmi, Federico
Arribarat, Germain
Bonneville, Fabrice
Larrue, Vincent
Péran, Patrice
author_sort Gollion, Cédric
collection PubMed
description INTRODUCTION: Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functions. This study aimed at investigating functional connectivity of insula subregions in MA. METHODS: Twenty-one interictal patients with MA were compared to 18 healthy controls (HC) and 12 interictal patients with migraine without aura (MO) and were scanned with functional MRI during the resting state. Functional coupling of the insula was comprehensively tested with 12 seeds located in the right and left, dorsal, middle, ventral, anterior and posterior insula, by using a seed-to-voxel analysis. RESULTS: Seed-to-voxel analysis revealed, in MA, a strong functional coupling of the right and left antero-dorsal insula with clusters located in the upper cerebellum. The overlap of these cerebellar clusters corresponded to the vermis VI. These functional couplings were not correlated to duration of MA, frequency of MA attacks nor time since last MA attack, and were not found in MO. DISCUSSION: The anterior insula and superior cerebellum, including vermis VI, are components of the central Autonomic Nervous System (ANS) network. As these regions are involved in the control of cardiovascular parasympathetic tone, we hypothesize that this connectivity may reflect the cardiovascular features of MA. CONCLUSION: The anterior dorsal insula is connected with vermis VI in MA patients in the resting state. This connectivity may reflect the cardiovascular features of MA. TRIAL REGISTRATION: NCT02708797.
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spelling pubmed-93897442022-08-20 Insular functional connectivity in migraine with aura Gollion, Cédric Lerebours, Fleur Nemmi, Federico Arribarat, Germain Bonneville, Fabrice Larrue, Vincent Péran, Patrice J Headache Pain Research INTRODUCTION: Insula plays an integrating role in sensory, affective, emotional, cognitive and autonomic functions in migraine, especially in migraine with aura (MA). Insula is functionally divided into 3 subregions, the dorsoanterior, the ventroanterior and the posterior insula respectively related to cognition, emotion, and somatosensory functions. This study aimed at investigating functional connectivity of insula subregions in MA. METHODS: Twenty-one interictal patients with MA were compared to 18 healthy controls (HC) and 12 interictal patients with migraine without aura (MO) and were scanned with functional MRI during the resting state. Functional coupling of the insula was comprehensively tested with 12 seeds located in the right and left, dorsal, middle, ventral, anterior and posterior insula, by using a seed-to-voxel analysis. RESULTS: Seed-to-voxel analysis revealed, in MA, a strong functional coupling of the right and left antero-dorsal insula with clusters located in the upper cerebellum. The overlap of these cerebellar clusters corresponded to the vermis VI. These functional couplings were not correlated to duration of MA, frequency of MA attacks nor time since last MA attack, and were not found in MO. DISCUSSION: The anterior insula and superior cerebellum, including vermis VI, are components of the central Autonomic Nervous System (ANS) network. As these regions are involved in the control of cardiovascular parasympathetic tone, we hypothesize that this connectivity may reflect the cardiovascular features of MA. CONCLUSION: The anterior dorsal insula is connected with vermis VI in MA patients in the resting state. This connectivity may reflect the cardiovascular features of MA. TRIAL REGISTRATION: NCT02708797. Springer Milan 2022-08-19 /pmc/articles/PMC9389744/ /pubmed/35982396 http://dx.doi.org/10.1186/s10194-022-01473-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Gollion, Cédric
Lerebours, Fleur
Nemmi, Federico
Arribarat, Germain
Bonneville, Fabrice
Larrue, Vincent
Péran, Patrice
Insular functional connectivity in migraine with aura
title Insular functional connectivity in migraine with aura
title_full Insular functional connectivity in migraine with aura
title_fullStr Insular functional connectivity in migraine with aura
title_full_unstemmed Insular functional connectivity in migraine with aura
title_short Insular functional connectivity in migraine with aura
title_sort insular functional connectivity in migraine with aura
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389744/
https://www.ncbi.nlm.nih.gov/pubmed/35982396
http://dx.doi.org/10.1186/s10194-022-01473-1
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