Cargando…

A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo

BACKGROUND: The Kin-Antwerp project aimed at improving the quality of care provided to patients with diabetes in Kinshasa, the Democratic Republic of the Congo in Central Africa, including the digitalisation of routine clinical data to improve patients’ follow-up. We aim to analyse the data of a stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Sagastume, Diana, Mertens, Elly, Sibongwere, Deogratias Katsuva, Dimbelolo, Jean-Claude, Kabundi, Jean Clovis Kalobu, de Man, Jeroen, Van Olmen, Josefien, Peñalvo, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389797/
https://www.ncbi.nlm.nih.gov/pubmed/35982436
http://dx.doi.org/10.1186/s12916-022-02458-2
_version_ 1784770534777552896
author Sagastume, Diana
Mertens, Elly
Sibongwere, Deogratias Katsuva
Dimbelolo, Jean-Claude
Kabundi, Jean Clovis Kalobu
de Man, Jeroen
Van Olmen, Josefien
Peñalvo, José L.
author_facet Sagastume, Diana
Mertens, Elly
Sibongwere, Deogratias Katsuva
Dimbelolo, Jean-Claude
Kabundi, Jean Clovis Kalobu
de Man, Jeroen
Van Olmen, Josefien
Peñalvo, José L.
author_sort Sagastume, Diana
collection PubMed
description BACKGROUND: The Kin-Antwerp project aimed at improving the quality of care provided to patients with diabetes in Kinshasa, the Democratic Republic of the Congo in Central Africa, including the digitalisation of routine clinical data to improve patients’ follow-up. We aim to analyse the data of a study population of Kin-Antwerp to characterise their demographic features, assess their achievement of glycemic target over time, and identify groups requiring prioritised attention. METHODS: We performed a secondary database analysis of routinely collected information from primary care patients with type 2 diabetes followed from 1991 to 2019. Data included demographics (age, sex), anthropometrics (weight, height), clinical parameters (blood pressure, plasma glucose), and anti-diabetic treatments. Achievement of glycemic target, defined as fasting plasma glucose < 126 mg/dL, over time was assessed using a multilevel mixed-effects logistic regression model. RESULTS: Our study population of patients with type 2 diabetes (N = 8976) comprised a higher proportion of women (67%) and patients between 40 and 65 years old (70.4%). At the first follow-up, most patients were on treatment with insulin (56.5%) and had glycemic levels under the target (79.9%). Women presented more often with obesity (27.4%) and high systolic blood pressure (41.8%) than men (8.6% and 37.0%, respectively). Patients had a median follow-up of 1.8 (interquartile range: 0.5–3.4) years. Overall, the odds of achieving glycemic target increased by 18.4% (odds ratio: 1.184, 95% CI: 1.130 to 1.239; p < 0.001) per year of follow-up. Stratified analyses suggested that the odds of achieving glycemic control over time increased among older patients (> 40 years), but not among younger patients (< 40 years). CONCLUSION: In our study population, an overall poor glycemic control was observed albeit with a modest improvement in the achievement of glycemic target throughout patients’ follow-up. Younger patients may benefit from prioritised attention to achieve glycemic targets. Based on the information provided by the database, continue monitoring and improvement of the project Kin-Antwerp is recommended. Introducing further efforts to improve type 2 diabetes management should include robust glycemia-monitoring tools and haemoglobin A1c, as well as further outlining self-management strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02458-2.
format Online
Article
Text
id pubmed-9389797
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-93897972022-08-20 A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo Sagastume, Diana Mertens, Elly Sibongwere, Deogratias Katsuva Dimbelolo, Jean-Claude Kabundi, Jean Clovis Kalobu de Man, Jeroen Van Olmen, Josefien Peñalvo, José L. BMC Med Research Article BACKGROUND: The Kin-Antwerp project aimed at improving the quality of care provided to patients with diabetes in Kinshasa, the Democratic Republic of the Congo in Central Africa, including the digitalisation of routine clinical data to improve patients’ follow-up. We aim to analyse the data of a study population of Kin-Antwerp to characterise their demographic features, assess their achievement of glycemic target over time, and identify groups requiring prioritised attention. METHODS: We performed a secondary database analysis of routinely collected information from primary care patients with type 2 diabetes followed from 1991 to 2019. Data included demographics (age, sex), anthropometrics (weight, height), clinical parameters (blood pressure, plasma glucose), and anti-diabetic treatments. Achievement of glycemic target, defined as fasting plasma glucose < 126 mg/dL, over time was assessed using a multilevel mixed-effects logistic regression model. RESULTS: Our study population of patients with type 2 diabetes (N = 8976) comprised a higher proportion of women (67%) and patients between 40 and 65 years old (70.4%). At the first follow-up, most patients were on treatment with insulin (56.5%) and had glycemic levels under the target (79.9%). Women presented more often with obesity (27.4%) and high systolic blood pressure (41.8%) than men (8.6% and 37.0%, respectively). Patients had a median follow-up of 1.8 (interquartile range: 0.5–3.4) years. Overall, the odds of achieving glycemic target increased by 18.4% (odds ratio: 1.184, 95% CI: 1.130 to 1.239; p < 0.001) per year of follow-up. Stratified analyses suggested that the odds of achieving glycemic control over time increased among older patients (> 40 years), but not among younger patients (< 40 years). CONCLUSION: In our study population, an overall poor glycemic control was observed albeit with a modest improvement in the achievement of glycemic target throughout patients’ follow-up. Younger patients may benefit from prioritised attention to achieve glycemic targets. Based on the information provided by the database, continue monitoring and improvement of the project Kin-Antwerp is recommended. Introducing further efforts to improve type 2 diabetes management should include robust glycemia-monitoring tools and haemoglobin A1c, as well as further outlining self-management strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02458-2. BioMed Central 2022-08-19 /pmc/articles/PMC9389797/ /pubmed/35982436 http://dx.doi.org/10.1186/s12916-022-02458-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Sagastume, Diana
Mertens, Elly
Sibongwere, Deogratias Katsuva
Dimbelolo, Jean-Claude
Kabundi, Jean Clovis Kalobu
de Man, Jeroen
Van Olmen, Josefien
Peñalvo, José L.
A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo
title A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo
title_full A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo
title_fullStr A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo
title_full_unstemmed A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo
title_short A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo
title_sort retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in kinshasa, democratic republic of the congo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389797/
https://www.ncbi.nlm.nih.gov/pubmed/35982436
http://dx.doi.org/10.1186/s12916-022-02458-2
work_keys_str_mv AT sagastumediana aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT mertenselly aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT sibongweredeogratiaskatsuva aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT dimbelolojeanclaude aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT kabundijeancloviskalobu aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT demanjeroen aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT vanolmenjosefien aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT penalvojosel aretrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT sagastumediana retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT mertenselly retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT sibongweredeogratiaskatsuva retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT dimbelolojeanclaude retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT kabundijeancloviskalobu retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT demanjeroen retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT vanolmenjosefien retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo
AT penalvojosel retrospectivedatabasestudyofthedemographicfeaturesandglycemiccontrolofpatientswithtype2diabetesinkinshasademocraticrepublicofthecongo