Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial

BACKGROUND: BCR-ABL1(T315I) mutations confer resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). Olverembatinib is a new potent BCR-ABL1 TKI with preclinical activity against T315I-mutated CML. In phase 1/2 studies, we explored the safety and efficacy of olverembatinib...

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Detalles Bibliográficos
Autores principales: Jiang, Qian, Li, Zongru, Qin, Yazhen, Li, Weiming, Xu, Na, Liu, Bingcheng, Zhang, Yanli, Meng, Li, Zhu, Huanling, Du, Xin, Chen, Suning, Liang, Yang, Hu, Yu, Liu, Xiaoli, Song, Yongping, Men, Lichuang, Chen, Zi, Niu, Qian, Wang, Hengbang, Lu, Ming, Yang, Dajun, Zhai, Yifan, Huang, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389804/
https://www.ncbi.nlm.nih.gov/pubmed/35982483
http://dx.doi.org/10.1186/s13045-022-01334-z

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