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PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival

In pediatric Hodgkin lymphoma (HL), the inability of the cytotoxic microenvironment induced by EBV presence to eliminate tumor cells could reflect the fact that the virus might be able to induce the expression of exhaustion markers to evade an immune response. Therefore, the expression of exhaustion...

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Autores principales: Jimenez, Oscar, Mangiaterra, Tamara, Colli, Sandra, García Lombardi, Mercedes, Preciado, Maria Victoria, De Matteo, Elena, Chabay, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390066/
https://www.ncbi.nlm.nih.gov/pubmed/35992809
http://dx.doi.org/10.3389/fonc.2022.957208
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author Jimenez, Oscar
Mangiaterra, Tamara
Colli, Sandra
García Lombardi, Mercedes
Preciado, Maria Victoria
De Matteo, Elena
Chabay, Paola
author_facet Jimenez, Oscar
Mangiaterra, Tamara
Colli, Sandra
García Lombardi, Mercedes
Preciado, Maria Victoria
De Matteo, Elena
Chabay, Paola
author_sort Jimenez, Oscar
collection PubMed
description In pediatric Hodgkin lymphoma (HL), the inability of the cytotoxic microenvironment induced by EBV presence to eliminate tumor cells could reflect the fact that the virus might be able to induce the expression of exhaustion markers to evade an immune response. Therefore, the expression of exhaustion markers in pediatric EBV–associated HL was evaluated. A balance between cytotoxic GrB and Th1 Tbet markers with regulatory Foxp3 was proved in EBV+ cases. In addition, exclusively in EBV-associated cHL, a correlation between PD-1 and LAG-3 expression was observed. Furthermore, those cases also displayed a trend to worse survival when they expressed LAG-3 and inferior event-free survival when both PD-1 and LAG-3 molecules were present. Therefore, even though a cytotoxic and inflammatory environment was supposed to be triggered by EBV presence in pediatric cHL, it seems that the virus may also induce the synergic effect of inhibitory molecules LAG-3 and PD-1 in this series. These observations may reflect the fact that the permissive and exhausted immune microenvironment succeeds to induce lymphomagenesis.
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spelling pubmed-93900662022-08-20 PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival Jimenez, Oscar Mangiaterra, Tamara Colli, Sandra García Lombardi, Mercedes Preciado, Maria Victoria De Matteo, Elena Chabay, Paola Front Oncol Oncology In pediatric Hodgkin lymphoma (HL), the inability of the cytotoxic microenvironment induced by EBV presence to eliminate tumor cells could reflect the fact that the virus might be able to induce the expression of exhaustion markers to evade an immune response. Therefore, the expression of exhaustion markers in pediatric EBV–associated HL was evaluated. A balance between cytotoxic GrB and Th1 Tbet markers with regulatory Foxp3 was proved in EBV+ cases. In addition, exclusively in EBV-associated cHL, a correlation between PD-1 and LAG-3 expression was observed. Furthermore, those cases also displayed a trend to worse survival when they expressed LAG-3 and inferior event-free survival when both PD-1 and LAG-3 molecules were present. Therefore, even though a cytotoxic and inflammatory environment was supposed to be triggered by EBV presence in pediatric cHL, it seems that the virus may also induce the synergic effect of inhibitory molecules LAG-3 and PD-1 in this series. These observations may reflect the fact that the permissive and exhausted immune microenvironment succeeds to induce lymphomagenesis. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9390066/ /pubmed/35992809 http://dx.doi.org/10.3389/fonc.2022.957208 Text en Copyright © 2022 Jimenez, Mangiaterra, Colli, García Lombardi, Preciado, De Matteo and Chabay https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jimenez, Oscar
Mangiaterra, Tamara
Colli, Sandra
García Lombardi, Mercedes
Preciado, Maria Victoria
De Matteo, Elena
Chabay, Paola
PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
title PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
title_full PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
title_fullStr PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
title_full_unstemmed PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
title_short PD-1 and LAG-3 expression in EBV-associated pediatric Hodgkin lymphoma has influence on survival
title_sort pd-1 and lag-3 expression in ebv-associated pediatric hodgkin lymphoma has influence on survival
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390066/
https://www.ncbi.nlm.nih.gov/pubmed/35992809
http://dx.doi.org/10.3389/fonc.2022.957208
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