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Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
BACKGROUND: Permanent pacemaker placement (PPM) is associated with morbidity following cardiac surgery. This study identified associations between PPM placement and 5-year outcomes for patients that require PPM following valvular surgery. METHODS: All patients who underwent valvular surgery at our m...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390660/ https://www.ncbi.nlm.nih.gov/pubmed/36003744 http://dx.doi.org/10.1016/j.xjon.2021.06.005 |
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author | Bianco, Valentino Kilic, Arman Aranda-Michel, Edgar Serna-Gallegos, Derek Dunn-Lewis, Courtenay Chen, Shangzhen Thoma, Floyd Navid, Forozan Sultan, Ibrahim |
author_facet | Bianco, Valentino Kilic, Arman Aranda-Michel, Edgar Serna-Gallegos, Derek Dunn-Lewis, Courtenay Chen, Shangzhen Thoma, Floyd Navid, Forozan Sultan, Ibrahim |
author_sort | Bianco, Valentino |
collection | PubMed |
description | BACKGROUND: Permanent pacemaker placement (PPM) is associated with morbidity following cardiac surgery. This study identified associations between PPM placement and 5-year outcomes for patients that require PPM following valvular surgery. METHODS: All patients who underwent valvular surgery at our medical center from 2011 to 2018 were considered for analysis. Multivariable analysis identified associations between PPM placement, mortality, and readmissions. Primary outcomes were operative complications and mortality. Secondary outcomes included 5-year survival and readmission. RESULTS: A total of 175 (4.86%) of 3602 valvular surgery patients required postoperative PPM. The PPM cohort had significantly worse baseline comorbidities, including greater Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) scores (3.8 vs 2.4 P < .0001). The PPM cohort had greater rates of blood product transfusion, prolonged ventilation, and new-onset atrial fibrillation. PPM placement was significantly associated with third-degree heart block (5.26; 95% confidence interval [95% CI], 1.00-27.53; P = .0496), ventricular fibrillation/tachycardia (3.90; 95% CI, 1.59-9.59; P = .01), and atrial fibrillation/flutter (1.53; 95% CI, 1.05-2.24; P = .03). On Kaplan-Meier estimates, 5-year survival (68.8% vs 83.1%; P = 01) was significantly reduced in the PPM cohort. Five-year all-cause readmission (60.4% vs 50.04%; P = .01) and heart failure readmission (35.5% vs 20.1%; P < .000) occurred more frequently in the PPM cohort. On multivariable Cox regression analysis, PPM placement (hazard ratio, 1.12; 95% CI, 0.84-1.50; P = .444) was not an independent predictor of mortality. On competing risk analysis, PPM (hazard ratio, 1.33; 95% CI, 0.99-1.80; P = .062) was not a predictor of hospital readmission. CONCLUSIONS: Valvular surgery patients who required postoperative PPM had elevated baseline operative risk. However, PPM implantation was not associated with mortality or readmission. |
format | Online Article Text |
id | pubmed-9390660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93906602022-08-23 Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes Bianco, Valentino Kilic, Arman Aranda-Michel, Edgar Serna-Gallegos, Derek Dunn-Lewis, Courtenay Chen, Shangzhen Thoma, Floyd Navid, Forozan Sultan, Ibrahim JTCVS Open Adult: Arrhythmias BACKGROUND: Permanent pacemaker placement (PPM) is associated with morbidity following cardiac surgery. This study identified associations between PPM placement and 5-year outcomes for patients that require PPM following valvular surgery. METHODS: All patients who underwent valvular surgery at our medical center from 2011 to 2018 were considered for analysis. Multivariable analysis identified associations between PPM placement, mortality, and readmissions. Primary outcomes were operative complications and mortality. Secondary outcomes included 5-year survival and readmission. RESULTS: A total of 175 (4.86%) of 3602 valvular surgery patients required postoperative PPM. The PPM cohort had significantly worse baseline comorbidities, including greater Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) scores (3.8 vs 2.4 P < .0001). The PPM cohort had greater rates of blood product transfusion, prolonged ventilation, and new-onset atrial fibrillation. PPM placement was significantly associated with third-degree heart block (5.26; 95% confidence interval [95% CI], 1.00-27.53; P = .0496), ventricular fibrillation/tachycardia (3.90; 95% CI, 1.59-9.59; P = .01), and atrial fibrillation/flutter (1.53; 95% CI, 1.05-2.24; P = .03). On Kaplan-Meier estimates, 5-year survival (68.8% vs 83.1%; P = 01) was significantly reduced in the PPM cohort. Five-year all-cause readmission (60.4% vs 50.04%; P = .01) and heart failure readmission (35.5% vs 20.1%; P < .000) occurred more frequently in the PPM cohort. On multivariable Cox regression analysis, PPM placement (hazard ratio, 1.12; 95% CI, 0.84-1.50; P = .444) was not an independent predictor of mortality. On competing risk analysis, PPM (hazard ratio, 1.33; 95% CI, 0.99-1.80; P = .062) was not a predictor of hospital readmission. CONCLUSIONS: Valvular surgery patients who required postoperative PPM had elevated baseline operative risk. However, PPM implantation was not associated with mortality or readmission. Elsevier 2021-06-16 /pmc/articles/PMC9390660/ /pubmed/36003744 http://dx.doi.org/10.1016/j.xjon.2021.06.005 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Adult: Arrhythmias Bianco, Valentino Kilic, Arman Aranda-Michel, Edgar Serna-Gallegos, Derek Dunn-Lewis, Courtenay Chen, Shangzhen Thoma, Floyd Navid, Forozan Sultan, Ibrahim Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
title | Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
title_full | Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
title_fullStr | Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
title_full_unstemmed | Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
title_short | Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
title_sort | permanent pacemaker placement following valve surgery is not independently associated with worse outcomes |
topic | Adult: Arrhythmias |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390660/ https://www.ncbi.nlm.nih.gov/pubmed/36003744 http://dx.doi.org/10.1016/j.xjon.2021.06.005 |
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