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Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes

BACKGROUND: Permanent pacemaker placement (PPM) is associated with morbidity following cardiac surgery. This study identified associations between PPM placement and 5-year outcomes for patients that require PPM following valvular surgery. METHODS: All patients who underwent valvular surgery at our m...

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Autores principales: Bianco, Valentino, Kilic, Arman, Aranda-Michel, Edgar, Serna-Gallegos, Derek, Dunn-Lewis, Courtenay, Chen, Shangzhen, Thoma, Floyd, Navid, Forozan, Sultan, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390660/
https://www.ncbi.nlm.nih.gov/pubmed/36003744
http://dx.doi.org/10.1016/j.xjon.2021.06.005
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author Bianco, Valentino
Kilic, Arman
Aranda-Michel, Edgar
Serna-Gallegos, Derek
Dunn-Lewis, Courtenay
Chen, Shangzhen
Thoma, Floyd
Navid, Forozan
Sultan, Ibrahim
author_facet Bianco, Valentino
Kilic, Arman
Aranda-Michel, Edgar
Serna-Gallegos, Derek
Dunn-Lewis, Courtenay
Chen, Shangzhen
Thoma, Floyd
Navid, Forozan
Sultan, Ibrahim
author_sort Bianco, Valentino
collection PubMed
description BACKGROUND: Permanent pacemaker placement (PPM) is associated with morbidity following cardiac surgery. This study identified associations between PPM placement and 5-year outcomes for patients that require PPM following valvular surgery. METHODS: All patients who underwent valvular surgery at our medical center from 2011 to 2018 were considered for analysis. Multivariable analysis identified associations between PPM placement, mortality, and readmissions. Primary outcomes were operative complications and mortality. Secondary outcomes included 5-year survival and readmission. RESULTS: A total of 175 (4.86%) of 3602 valvular surgery patients required postoperative PPM. The PPM cohort had significantly worse baseline comorbidities, including greater Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) scores (3.8 vs 2.4 P < .0001). The PPM cohort had greater rates of blood product transfusion, prolonged ventilation, and new-onset atrial fibrillation. PPM placement was significantly associated with third-degree heart block (5.26; 95% confidence interval [95% CI], 1.00-27.53; P = .0496), ventricular fibrillation/tachycardia (3.90; 95% CI, 1.59-9.59; P = .01), and atrial fibrillation/flutter (1.53; 95% CI, 1.05-2.24; P = .03). On Kaplan-Meier estimates, 5-year survival (68.8% vs 83.1%; P = 01) was significantly reduced in the PPM cohort. Five-year all-cause readmission (60.4% vs 50.04%; P = .01) and heart failure readmission (35.5% vs 20.1%; P < .000) occurred more frequently in the PPM cohort. On multivariable Cox regression analysis, PPM placement (hazard ratio, 1.12; 95% CI, 0.84-1.50; P = .444) was not an independent predictor of mortality. On competing risk analysis, PPM (hazard ratio, 1.33; 95% CI, 0.99-1.80; P = .062) was not a predictor of hospital readmission. CONCLUSIONS: Valvular surgery patients who required postoperative PPM had elevated baseline operative risk. However, PPM implantation was not associated with mortality or readmission.
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spelling pubmed-93906602022-08-23 Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes Bianco, Valentino Kilic, Arman Aranda-Michel, Edgar Serna-Gallegos, Derek Dunn-Lewis, Courtenay Chen, Shangzhen Thoma, Floyd Navid, Forozan Sultan, Ibrahim JTCVS Open Adult: Arrhythmias BACKGROUND: Permanent pacemaker placement (PPM) is associated with morbidity following cardiac surgery. This study identified associations between PPM placement and 5-year outcomes for patients that require PPM following valvular surgery. METHODS: All patients who underwent valvular surgery at our medical center from 2011 to 2018 were considered for analysis. Multivariable analysis identified associations between PPM placement, mortality, and readmissions. Primary outcomes were operative complications and mortality. Secondary outcomes included 5-year survival and readmission. RESULTS: A total of 175 (4.86%) of 3602 valvular surgery patients required postoperative PPM. The PPM cohort had significantly worse baseline comorbidities, including greater Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) scores (3.8 vs 2.4 P < .0001). The PPM cohort had greater rates of blood product transfusion, prolonged ventilation, and new-onset atrial fibrillation. PPM placement was significantly associated with third-degree heart block (5.26; 95% confidence interval [95% CI], 1.00-27.53; P = .0496), ventricular fibrillation/tachycardia (3.90; 95% CI, 1.59-9.59; P = .01), and atrial fibrillation/flutter (1.53; 95% CI, 1.05-2.24; P = .03). On Kaplan-Meier estimates, 5-year survival (68.8% vs 83.1%; P = 01) was significantly reduced in the PPM cohort. Five-year all-cause readmission (60.4% vs 50.04%; P = .01) and heart failure readmission (35.5% vs 20.1%; P < .000) occurred more frequently in the PPM cohort. On multivariable Cox regression analysis, PPM placement (hazard ratio, 1.12; 95% CI, 0.84-1.50; P = .444) was not an independent predictor of mortality. On competing risk analysis, PPM (hazard ratio, 1.33; 95% CI, 0.99-1.80; P = .062) was not a predictor of hospital readmission. CONCLUSIONS: Valvular surgery patients who required postoperative PPM had elevated baseline operative risk. However, PPM implantation was not associated with mortality or readmission. Elsevier 2021-06-16 /pmc/articles/PMC9390660/ /pubmed/36003744 http://dx.doi.org/10.1016/j.xjon.2021.06.005 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Adult: Arrhythmias
Bianco, Valentino
Kilic, Arman
Aranda-Michel, Edgar
Serna-Gallegos, Derek
Dunn-Lewis, Courtenay
Chen, Shangzhen
Thoma, Floyd
Navid, Forozan
Sultan, Ibrahim
Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
title Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
title_full Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
title_fullStr Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
title_full_unstemmed Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
title_short Permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
title_sort permanent pacemaker placement following valve surgery is not independently associated with worse outcomes
topic Adult: Arrhythmias
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390660/
https://www.ncbi.nlm.nih.gov/pubmed/36003744
http://dx.doi.org/10.1016/j.xjon.2021.06.005
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