Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. However, a drug that directly couples targeting of a metabolic dependency with the induction of cell death in cancer cells has largely remained elusive. Here we report that the drug-like small-molecul...

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Detalles Bibliográficos
Autores principales: Garciaz, Sylvain, Guirguis, Andrew A., Müller, Sebastian, Brown, Fiona C., Chan, Yih-Chih, Motazedian, Ali, Rowe, Caitlin L., Kuzich, James A., Chan, Kah Lok, Tran, Kevin, Smith, Lorey, MacPherson, Laura, Liddicoat, Brian, Lam, Enid Y.N., Cañeque, Tatiana, Burr, Marian L., Litalien, Véronique, Pomilio, Giovanna, Poplineau, Mathilde, Duprez, Estelle, Dawson, Sarah-Jane, Ramm, Georg, Cox, Andrew G., Brown, Kristin K., Huang, David C.S., Wei, Andrew H., McArthur, Kate, Rodriguez, Raphaël, Dawson, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390741/
https://www.ncbi.nlm.nih.gov/pubmed/34862195
http://dx.doi.org/10.1158/2159-8290.CD-21-0522

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