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Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right fro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital Universitário da Universidade de São Paulo
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390789/ https://www.ncbi.nlm.nih.gov/pubmed/35996712 http://dx.doi.org/10.4322/acr.2021.394 |
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author | Gaggero, Gabriele Campora, Michela Taietti, Davide Cerruti, Giannamaria Lo Bue, Enrico Truffelli, Monica Ceraudo, Marco Fiaschi, Pietro |
author_facet | Gaggero, Gabriele Campora, Michela Taietti, Davide Cerruti, Giannamaria Lo Bue, Enrico Truffelli, Monica Ceraudo, Marco Fiaschi, Pietro |
author_sort | Gaggero, Gabriele |
collection | PubMed |
description | Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature. It has been categorized as a grade I tumor in the 2021 World Health Organization (WHO) classification central nervous system. Due to the rarity, this meningioma variant origin and biological behavior are still not clear. Immunohistochemistry profile showed prominent PD-L1 expression, leading to additional interrogation on LPRM immunomorphological characteristics, the significance of the inflammatory tumoral microenvironment and its correlation with the immune-checkpoints. |
format | Online Article Text |
id | pubmed-9390789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hospital Universitário da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-93907892022-08-21 Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression Gaggero, Gabriele Campora, Michela Taietti, Davide Cerruti, Giannamaria Lo Bue, Enrico Truffelli, Monica Ceraudo, Marco Fiaschi, Pietro Autops Case Rep Clinical Case Report Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature. It has been categorized as a grade I tumor in the 2021 World Health Organization (WHO) classification central nervous system. Due to the rarity, this meningioma variant origin and biological behavior are still not clear. Immunohistochemistry profile showed prominent PD-L1 expression, leading to additional interrogation on LPRM immunomorphological characteristics, the significance of the inflammatory tumoral microenvironment and its correlation with the immune-checkpoints. Hospital Universitário da Universidade de São Paulo 2022-08-12 /pmc/articles/PMC9390789/ /pubmed/35996712 http://dx.doi.org/10.4322/acr.2021.394 Text en Copyright © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Case Report Gaggero, Gabriele Campora, Michela Taietti, Davide Cerruti, Giannamaria Lo Bue, Enrico Truffelli, Monica Ceraudo, Marco Fiaschi, Pietro Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression |
title | Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression |
title_full | Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression |
title_fullStr | Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression |
title_full_unstemmed | Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression |
title_short | Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression |
title_sort | lymphoplasmacyte-rich meningioma with hematologic signs and pd-l1 over-expression |
topic | Clinical Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390789/ https://www.ncbi.nlm.nih.gov/pubmed/35996712 http://dx.doi.org/10.4322/acr.2021.394 |
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