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Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression

Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right fro...

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Autores principales: Gaggero, Gabriele, Campora, Michela, Taietti, Davide, Cerruti, Giannamaria, Lo Bue, Enrico, Truffelli, Monica, Ceraudo, Marco, Fiaschi, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital Universitário da Universidade de São Paulo 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390789/
https://www.ncbi.nlm.nih.gov/pubmed/35996712
http://dx.doi.org/10.4322/acr.2021.394
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author Gaggero, Gabriele
Campora, Michela
Taietti, Davide
Cerruti, Giannamaria
Lo Bue, Enrico
Truffelli, Monica
Ceraudo, Marco
Fiaschi, Pietro
author_facet Gaggero, Gabriele
Campora, Michela
Taietti, Davide
Cerruti, Giannamaria
Lo Bue, Enrico
Truffelli, Monica
Ceraudo, Marco
Fiaschi, Pietro
author_sort Gaggero, Gabriele
collection PubMed
description Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature. It has been categorized as a grade I tumor in the 2021 World Health Organization (WHO) classification central nervous system. Due to the rarity, this meningioma variant origin and biological behavior are still not clear. Immunohistochemistry profile showed prominent PD-L1 expression, leading to additional interrogation on LPRM immunomorphological characteristics, the significance of the inflammatory tumoral microenvironment and its correlation with the immune-checkpoints.
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spelling pubmed-93907892022-08-21 Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression Gaggero, Gabriele Campora, Michela Taietti, Davide Cerruti, Giannamaria Lo Bue, Enrico Truffelli, Monica Ceraudo, Marco Fiaschi, Pietro Autops Case Rep Clinical Case Report Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature. It has been categorized as a grade I tumor in the 2021 World Health Organization (WHO) classification central nervous system. Due to the rarity, this meningioma variant origin and biological behavior are still not clear. Immunohistochemistry profile showed prominent PD-L1 expression, leading to additional interrogation on LPRM immunomorphological characteristics, the significance of the inflammatory tumoral microenvironment and its correlation with the immune-checkpoints. Hospital Universitário da Universidade de São Paulo 2022-08-12 /pmc/articles/PMC9390789/ /pubmed/35996712 http://dx.doi.org/10.4322/acr.2021.394 Text en Copyright © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Case Report
Gaggero, Gabriele
Campora, Michela
Taietti, Davide
Cerruti, Giannamaria
Lo Bue, Enrico
Truffelli, Monica
Ceraudo, Marco
Fiaschi, Pietro
Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
title Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
title_full Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
title_fullStr Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
title_full_unstemmed Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
title_short Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression
title_sort lymphoplasmacyte-rich meningioma with hematologic signs and pd-l1 over-expression
topic Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390789/
https://www.ncbi.nlm.nih.gov/pubmed/35996712
http://dx.doi.org/10.4322/acr.2021.394
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