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A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and ti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390864/ https://www.ncbi.nlm.nih.gov/pubmed/36000117 http://dx.doi.org/10.7759/cureus.27069 |
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author | Tran, Sydney Thakkar, Radhika Gillie, Monica Anderson, Jeffrey |
author_facet | Tran, Sydney Thakkar, Radhika Gillie, Monica Anderson, Jeffrey |
author_sort | Tran, Sydney |
collection | PubMed |
description | We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Presentation varies from mild hyperextensibility of the skin and joints to debilitating physical disabilities and vascular complications because of genetic defects in type one and three collagen synthesis. Collagen is the most abundant protein in nearly all parts of the body and errors in the production of this protein have widespread effects. Therefore, we suggest a multidisciplinary approach to the management of patients with EDS, with an emphasis on patient education, to aid in the prevention and early detection of complications. |
format | Online Article Text |
id | pubmed-9390864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-93908642022-08-22 A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome Tran, Sydney Thakkar, Radhika Gillie, Monica Anderson, Jeffrey Cureus Genetics We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Presentation varies from mild hyperextensibility of the skin and joints to debilitating physical disabilities and vascular complications because of genetic defects in type one and three collagen synthesis. Collagen is the most abundant protein in nearly all parts of the body and errors in the production of this protein have widespread effects. Therefore, we suggest a multidisciplinary approach to the management of patients with EDS, with an emphasis on patient education, to aid in the prevention and early detection of complications. Cureus 2022-07-20 /pmc/articles/PMC9390864/ /pubmed/36000117 http://dx.doi.org/10.7759/cureus.27069 Text en Copyright © 2022, Tran et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Genetics Tran, Sydney Thakkar, Radhika Gillie, Monica Anderson, Jeffrey A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome |
title | A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome |
title_full | A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome |
title_fullStr | A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome |
title_full_unstemmed | A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome |
title_short | A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome |
title_sort | case of early osteoarthritis in a patient with ehlers-danlos syndrome |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390864/ https://www.ncbi.nlm.nih.gov/pubmed/36000117 http://dx.doi.org/10.7759/cureus.27069 |
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