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A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome

We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and ti...

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Detalles Bibliográficos
Autores principales: Tran, Sydney, Thakkar, Radhika, Gillie, Monica, Anderson, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390864/
https://www.ncbi.nlm.nih.gov/pubmed/36000117
http://dx.doi.org/10.7759/cureus.27069
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author Tran, Sydney
Thakkar, Radhika
Gillie, Monica
Anderson, Jeffrey
author_facet Tran, Sydney
Thakkar, Radhika
Gillie, Monica
Anderson, Jeffrey
author_sort Tran, Sydney
collection PubMed
description We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Presentation varies from mild hyperextensibility of the skin and joints to debilitating physical disabilities and vascular complications because of genetic defects in type one and three collagen synthesis. Collagen is the most abundant protein in nearly all parts of the body and errors in the production of this protein have widespread effects. Therefore, we suggest a multidisciplinary approach to the management of patients with EDS, with an emphasis on patient education, to aid in the prevention and early detection of complications.
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spelling pubmed-93908642022-08-22 A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome Tran, Sydney Thakkar, Radhika Gillie, Monica Anderson, Jeffrey Cureus Genetics We present a case of early onset osteoarthritis in a patient with Ehlers-Danlos syndrome (EDS) and a history of developmental dysplasia of the hip. Ehlers-Danlos syndrome (EDS) is part of a wide spectrum of connective tissue disorders characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Presentation varies from mild hyperextensibility of the skin and joints to debilitating physical disabilities and vascular complications because of genetic defects in type one and three collagen synthesis. Collagen is the most abundant protein in nearly all parts of the body and errors in the production of this protein have widespread effects. Therefore, we suggest a multidisciplinary approach to the management of patients with EDS, with an emphasis on patient education, to aid in the prevention and early detection of complications. Cureus 2022-07-20 /pmc/articles/PMC9390864/ /pubmed/36000117 http://dx.doi.org/10.7759/cureus.27069 Text en Copyright © 2022, Tran et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Tran, Sydney
Thakkar, Radhika
Gillie, Monica
Anderson, Jeffrey
A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
title A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
title_full A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
title_fullStr A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
title_full_unstemmed A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
title_short A Case of Early Osteoarthritis in a Patient With Ehlers-Danlos Syndrome
title_sort case of early osteoarthritis in a patient with ehlers-danlos syndrome
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390864/
https://www.ncbi.nlm.nih.gov/pubmed/36000117
http://dx.doi.org/10.7759/cureus.27069
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