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T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients
The cognitive impairment, depression, a decrease in the ability to perform activities of daily living (ADLs), and salivary gland dysfunction, as indicated by the reduction of alpha-amylase activity, have been reported in patients with type 2 diabetes (T2DM). However, the effects of depression on cog...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390925/ https://www.ncbi.nlm.nih.gov/pubmed/35984808 http://dx.doi.org/10.1371/journal.pone.0273327 |
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author | Thummasorn, Savitree Apichai, Sopida Chupradit, Supat Sirisattayawong, Pornpen Chaiwong, Pachpilai Sriwichaiin, Sirawit Pratchayasakul, Wasana Chattipakorn, Nipon Chattipakorn, Siriporn C. |
author_facet | Thummasorn, Savitree Apichai, Sopida Chupradit, Supat Sirisattayawong, Pornpen Chaiwong, Pachpilai Sriwichaiin, Sirawit Pratchayasakul, Wasana Chattipakorn, Nipon Chattipakorn, Siriporn C. |
author_sort | Thummasorn, Savitree |
collection | PubMed |
description | The cognitive impairment, depression, a decrease in the ability to perform activities of daily living (ADLs), and salivary gland dysfunction, as indicated by the reduction of alpha-amylase activity, have been reported in patients with type 2 diabetes (T2DM). However, the effects of depression on cognitive function, salivary alpha-amylase activity, and ADLs in T2DM patients have never been investigated. In this study, 115 participants were divided into three groups, including 30 healthy people, 50 T2DM patients without depression, and 35 T2DM patients with depression. Then, the cognitive function, the level of depression, salivary-alpha amylase activity, ADLs, and metabolic parameters were determined. Results showed that T2DM patients had hyperglycemia and cognitive impairment. A decrease in the salivary alpha-amylase activity was observed in T2DM patients. Interestingly, T2DM patients with depression had higher level of hyperglycemia and cognitive impairment than T2DM patients. Additionally, cognitive function was associated with the salivary-alpha amylase activity in T2DM without depression, while the severity of depression was associated with the salivary-alpha amylase activity in T2DM patients with depression. Therefore, we concluded that T2DM caused the impairment of metabolism, decreased salivary alpha-amylase activity, and cognitive impairment. Furthermore, T2DM patients with depression had higher level of hyperglycemia and cognitive decline than T2DM patients. |
format | Online Article Text |
id | pubmed-9390925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-93909252022-08-20 T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients Thummasorn, Savitree Apichai, Sopida Chupradit, Supat Sirisattayawong, Pornpen Chaiwong, Pachpilai Sriwichaiin, Sirawit Pratchayasakul, Wasana Chattipakorn, Nipon Chattipakorn, Siriporn C. PLoS One Research Article The cognitive impairment, depression, a decrease in the ability to perform activities of daily living (ADLs), and salivary gland dysfunction, as indicated by the reduction of alpha-amylase activity, have been reported in patients with type 2 diabetes (T2DM). However, the effects of depression on cognitive function, salivary alpha-amylase activity, and ADLs in T2DM patients have never been investigated. In this study, 115 participants were divided into three groups, including 30 healthy people, 50 T2DM patients without depression, and 35 T2DM patients with depression. Then, the cognitive function, the level of depression, salivary-alpha amylase activity, ADLs, and metabolic parameters were determined. Results showed that T2DM patients had hyperglycemia and cognitive impairment. A decrease in the salivary alpha-amylase activity was observed in T2DM patients. Interestingly, T2DM patients with depression had higher level of hyperglycemia and cognitive impairment than T2DM patients. Additionally, cognitive function was associated with the salivary-alpha amylase activity in T2DM without depression, while the severity of depression was associated with the salivary-alpha amylase activity in T2DM patients with depression. Therefore, we concluded that T2DM caused the impairment of metabolism, decreased salivary alpha-amylase activity, and cognitive impairment. Furthermore, T2DM patients with depression had higher level of hyperglycemia and cognitive decline than T2DM patients. Public Library of Science 2022-08-19 /pmc/articles/PMC9390925/ /pubmed/35984808 http://dx.doi.org/10.1371/journal.pone.0273327 Text en © 2022 Thummasorn et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Thummasorn, Savitree Apichai, Sopida Chupradit, Supat Sirisattayawong, Pornpen Chaiwong, Pachpilai Sriwichaiin, Sirawit Pratchayasakul, Wasana Chattipakorn, Nipon Chattipakorn, Siriporn C. T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients |
title | T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients |
title_full | T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients |
title_fullStr | T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients |
title_full_unstemmed | T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients |
title_short | T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients |
title_sort | t2dm patients with depression have higher levels of hyperglycemia and cognitive decline than t2dm patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390925/ https://www.ncbi.nlm.nih.gov/pubmed/35984808 http://dx.doi.org/10.1371/journal.pone.0273327 |
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