RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification

Ectopic endochondral ossification in the tendon/ligament is caused by repetitive mechanical overload or inflammation. Tendon stem/progenitor cells (TSPCs) contribute to tissue repair, and some express lubricin [proteoglycan 4 (PRG4)]. However, the mechanisms of ectopic ossification and association o...

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Detalles Bibliográficos
Autores principales: Tachibana, Naohiro, Chijimatsu, Ryota, Okada, Hiroyuki, Oichi, Takeshi, Taniguchi, Yuki, Maenohara, Yuji, Miyahara, Junya, Ishikura, Hisatoshi, Iwanaga, Yasuhide, Arino, Yusuke, Nagata, Kosei, Nakamoto, Hideki, Kato, So, Doi, Toru, Matsubayashi, Yoshitaka, Oshima, Yasushi, Terashima, Asuka, Omata, Yasunori, Yano, Fumiko, Maeda, Shingo, Ikegawa, Shiro, Seki, Masahide, Suzuki, Yutaka, Tanaka, Sakae, Saito, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390986/
https://www.ncbi.nlm.nih.gov/pubmed/35984875
http://dx.doi.org/10.1126/sciadv.abn2138

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