A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine–related JAK-STAT signal

Janus kinases (JAKs) play a critical role in immune responses by relaying signals from more than 50 cytokines, making them attractive therapeutic targets for autoimmune diseases. Although approved JAK inhibitors have demonstrated clinical efficacy, they target a broad spectrum of cytokines, which re...

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Detalles Bibliográficos
Autores principales: Chen, Chengjuan, Yin, Yuan, Shi, Gaona, Zhou, Yu, Shao, Shuai, Wei, Yazi, Wu, Lei, Zhang, Dayong, Sun, Lan, Zhang, Tiantai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390995/
https://www.ncbi.nlm.nih.gov/pubmed/35984890
http://dx.doi.org/10.1126/sciadv.abo4363

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